Seki K, Seki M, Okumura T, Huang K
Am J Obstet Gynecol. 1976 Jan 15;124(2):125-8. doi: 10.1016/s0002-9378(16)33286-0.
Serum prolactin (PRL) levels were determined by radioimmunoassay in 12 normal, menstruating women and in 26 infetile women with ovarian dysfunction for one cycle or for about 30 days in amenorrheic women. Galactorrhea was not observed. No significant change in serum PRL levels was observed throughout the normal, menstrual cycle. Of the 26 patients with ovarian dysfunction, seven showed PRL levels higher than normal. Twelve of the 26 patients were treated with clomiphene citrate (Clomid), 100 mg, daily for 5 days. Ovulation occurred in seven, and pregnancy was achi-ved in two of them. Serum PR;, follicle-stimulating hormone, and luteinizing hormone were measured for a preceding control cycle and during the cycle following Clomid treatment in the 12 patients. The serum PRL levels were normal during the control cycle in five of the patients who ovulated with Clomid and high in four patients who failed to ovulate. Although serum PRL levels were not significantly changed by Clomid in the patients who ovulated with the drug, they were markedly decreased during and immediately after Clomid treatment in patients who failed to ovulate with Clomid.
采用放射免疫分析法测定了12名正常月经女性以及26名卵巢功能障碍的不孕女性的血清催乳素（PRL）水平，其中闭经女性检测一个周期或约30天。未观察到溢乳现象。在整个正常月经周期中，血清PRL水平未观察到显著变化。在26名卵巢功能障碍患者中，7名患者的PRL水平高于正常。26名患者中的12名接受了枸橼酸氯米芬（克罗米芬）治疗，每日100毫克，共5天。7名患者排卵，其中2名患者怀孕。对12名患者在服用克罗米芬前的对照周期以及治疗后的周期中测量了血清PRL、促卵泡激素和促黄体生成素。在服用克罗米芬后排卵的5名患者中，对照周期血清PRL水平正常，而4名未排卵患者的血清PRL水平较高。虽然服用克罗米芬后排卵的患者血清PRL水平无显著变化，但未排卵患者在服用克罗米芬期间及之后血清PRL水平显著降低。
