Castor C W, Yaron M
Arch Phys Med Rehabil. 1976 Jan;57(1):5-9.
The effects of increasing environmental temperature were studied in two normal and two rheumatoid human synovial cell cultures. Control cultures showed an increased rate of hyaluronate synthesis and glucolysis as temperature was increased from 30 C to 39 C. Cultures which were activated (stimulated by a connective tissue activating peptide, CTAP) showed an especially striking increase in hyaluronic acid synthesis, glucose uptake and lactate formation at 36 C and 38 C. The data suggest that small changes in joint temperature may be associated with profound alterations in synovial metabolic activity.
在两种正常人和两种类风湿病人的滑膜细胞培养物中研究了环境温度升高的影响。对照培养物显示，当温度从30℃升高到39℃时，透明质酸盐合成和糖酵解速率增加。被激活的培养物（由结缔组织激活肽CTAP刺激）在36℃和38℃时，透明质酸合成、葡萄糖摄取和乳酸生成尤其显著增加。数据表明，关节温度的微小变化可能与滑膜代谢活性的深刻改变有关。
