结缔组织激活。十一、血小板因子对糖胺聚糖和DNA形成的刺激作用。
Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor.
作者信息
Castor C W, Ritchie J C, Scott M E, Whitney S L
出版信息
Arthritis Rheum. 1977 Apr;20(3):859-68. doi: 10.1002/art.1780200316.
This report describes a small basic protein found in human platelets which stimulates hyaluronic acid formation, glucose uptake, and lactate formation in several types of human connective tissue cells. In addition, it stimulates in incorporation of [3H] methyl thymidine into DNA in human synovial cell cultures. This platelet factor (connective tissue activating peptide-II, CTAP-III) clearly differs form CTAP-I, found in human lymphocytes, and may play a role as a mediator of the inflammatory process.
本报告描述了一种在人血小板中发现的小碱性蛋白，它能刺激几种类型的人结缔组织细胞中透明质酸的形成、葡萄糖摄取和乳酸生成。此外，它还能刺激人滑膜细胞培养物中[3H]甲基胸苷掺入DNA。这种血小板因子（结缔组织激活肽-II，CTAP-III）明显不同于在人淋巴细胞中发现的CTAP-I，可能作为炎症过程的介质发挥作用。
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