孕酮对非洲爪蟾分离的成熟卵母细胞氨基酸摄取作用的性质。
Nature of progesterone action on amino acid uptake by isolated full-grown oocyte of Xenopus laevis.
作者信息
Bellé R, Marot J, Ozon R
出版信息
Biochim Biophys Acta. 1976 Jan 21;419(2):342-8. doi: 10.1016/0005-2736(76)90360-6.
PMID:1247560
Abstract
L-leucine uptake into full-grown oocytes of Xenopus laevis is a saturable process which is Na+ dependent and presumably coupled to Na+ gradient. Our results indicate that progesterone (10(-6) M) Blocks abruptly, around the germinal vesicle breakdown, the saturable transport of L-leucine. p-Chloromercuribenzoate (10(-4) M) induces maturation and after a short lag of time strongly inhibits L-leucine uptake. Cycloheximide prevents progesterone-induced maturation and permeability changes.
摘要
L-亮氨酸进入非洲爪蟾成熟卵母细胞是一个可饱和的过程，该过程依赖于Na⁺，并且可能与Na⁺梯度偶联。我们的结果表明，孕酮（10⁻⁶ M）在生发泡破裂前后会突然阻断L-亮氨酸的可饱和转运。对氯汞苯甲酸（10⁻⁴ M）诱导成熟，经过短暂延迟后强烈抑制L-亮氨酸摄取。环己酰亚胺可防止孕酮诱导的成熟和通透性变化。
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