Bruze Magnus, Zimerson Erik
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden.
Am J Contact Dermat. 2002 Dec;13(4):198-200. doi: 10.1053/ajcd.2002.36637.
In patients hypersensitive to phenol formaldehyde resin (PFR) it is, for therapeutic and preventive reasons, important to know the identity of the primary sensitizing substances, their sensitizing capacity, as well as their cross-reaction patterns. When elucidating the issue of cross reactivity in patients with contact allergy to simple methylol phenols (MP), o-cresol was shown to be a contact sensitizer. Besides cross reactivity, contamination of one or more MP(s) in o-cresol as well as o-cresol being a sensitizer of its own in PFR were possible explanations of the simultaneous positive patch test reactions to MP and o-cresol.
The aim of this study was to investigate if the simultaneous allergic reactions to PFR and o-cresol could be explained by the presence of this substance in PFR.
Patch testing, high-pressure liquid chromatography (HPLC), nuclear magnetic resonance spectrometry (NMR), gas chromatography (GC), and mass spectrometry (MS) were used.
o-Cresol was isolated from the specific PFR used in our standard patch test series and identified. The concentration in the resin was 0.066% wt/wt.
The current study establishes o-cresol as a contact sensitizer in a PFR. The observed reactions to o-cresol could be on the basis of cross reactivity or primary sensitization.
对于对酚醛树脂（PFR）过敏的患者，出于治疗和预防的原因，了解主要致敏物质的身份、它们的致敏能力以及交叉反应模式非常重要。在阐明对简单羟甲基苯酚（MP）接触过敏患者的交叉反应问题时，邻甲酚被证明是一种接触致敏原。除了交叉反应外，邻甲酚中一种或多种MP的污染以及邻甲酚本身作为PFR中的致敏原可能是对MP和邻甲酚同时进行斑贴试验呈阳性反应的原因。
本研究的目的是调查对PFR和邻甲酚的同时过敏反应是否可以用PFR中该物质的存在来解释。
采用斑贴试验、高压液相色谱（HPLC）、核磁共振光谱（NMR）、气相色谱（GC）和质谱（MS）。
从我们标准斑贴试验系列中使用的特定PFR中分离并鉴定出邻甲酚。树脂中的浓度为0.066%重量/重量。
本研究确定邻甲酚是PFR中的一种接触致敏原。观察到的对邻甲酚的反应可能基于交叉反应或原发性致敏。
