[实验性精索静脉曲张大鼠睾丸中白细胞介素-1和一氧化氮水平的变化]
[The changes of IL-1 and NO levels in the testes of rats with experimental varicocele].
作者信息
Chen Li-Ping, Wang Shu-Qiu, Zhao Yu-Zhen, Liu Lei, Wang Shu-Xiang, Lu Ya-Zhen
机构信息
Department of Obstetric and Gynecology, Jiamusi Center Hospital, Jiamusi, Heilongjiang 154002, China.
出版信息
Zhonghua Nan Ke Xue. 2002;8(2):125-6.
OBJECTIVES
To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC.
METHODS
Male adult Wistar rats were divided into two groups randomly, VC group (n = 30) and pseudo-operation group (n = 20), and the levels of IL-1 and NO in the testes were determined and compared.
RESULTS
The levels of IL-1 and No of left tests in VC group were higher than those in pseudo-operation group, respectively(P < 0.01). While the levels of IL-1 and NO of right testes between two groups were not significantly different (P > 0.05). More over, the level of IL-1 correlated significantly with that of NO(r = 0.572, P < 0.01).
CONCLUSIONS
The results revealed that the changes of IL-1 and NO levels in the testes of rats with VC might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility.
目的
评估精索静脉曲张（VC）对VC大鼠睾丸中白细胞介素-1（IL-1）和一氧化氮（NO）水平的影响。
方法
将成年雄性Wistar大鼠随机分为两组，VC组（n = 30）和假手术组（n = 20），测定并比较睾丸中IL-1和NO的水平。
结果
VC组左侧睾丸的IL-1和NO水平分别高于假手术组（P < 0.01）。而两组右侧睾丸的IL-1和NO水平无显著差异（P > 0.05）。此外，IL-1水平与NO水平显著相关（r = 0.572，P < 0.01）。
结论
结果表明，VC大鼠睾丸中IL-1和NO水平的变化可能是导致睾丸损伤、精子发生紊乱甚至不育的原因。
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