阿霉素对体外培养的需氧和缺氧中国仓鼠V79细胞的细胞毒性。
Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro.
作者信息
Smith E, Stratford I J, Adams G E
出版信息
Br J Cancer. 1980 Oct;42(4):568-73. doi: 10.1038/bjc.1980.281.
Abstract
Mammalian cells (V79-379A) in suspension culture rendered chronically hypoxic showed greater resistance to Adriamycin than exponentially growing aerobic cells. Resistance to Adriamycin increased as a function of the time cells were held under hypoxic conditions, with maximal resistance after 6 h. Chronically hypoxic cells retained their resistance when reoxygenated, and did not return to their original sensitivity until they had been in air for 24 h. Uptake of Adriamycin was similar for chronically hypoxic and exponentially growing aerobic cells, but much more than for plateau-phase cells. These findings suggest that chronically hypoxic cells in tumours may be resistant to this drug.
摘要
悬浮培养的哺乳动物细胞（V79 - 379A）经长期缺氧处理后，与指数生长的需氧细胞相比，对阿霉素表现出更强的抗性。对阿霉素的抗性随细胞在缺氧条件下保持的时间而增加，在6小时后达到最大抗性。长期缺氧的细胞在复氧后仍保持其抗性，直到在空气中放置24小时后才恢复到原来的敏感性。长期缺氧细胞和指数生长的需氧细胞对阿霉素的摄取相似，但远高于平台期细胞。这些发现表明肿瘤中的长期缺氧细胞可能对这种药物具有抗性。
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2
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3
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5
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