Hochrein Hubertus, O'Keeffe Meredith, Wagner Hermann
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany.
Hum Immunol. 2002 Dec;63(12):1103-10. doi: 10.1016/s0198-8859(02)00748-6.
By virtue of their enormous potential to produce type I interferons it is clear that plasmacytoid dendritic cells are major players in the host defense against viruses and various pathogens. Plasmacytoid dendritic cells were first identified in humans and very recently the mouse equivalents have been isolated. This review focuses, where possible, on a comparison between the cells in these two species. The mouse and human plasmacytoid DC are remarkably similar in surface phenotype and they display similar responses to pathogenic stimuli. The discovery of the mouse plasmacytoid dendritic cells has allowed for further biological properties of these cells to be investigated and it is now clear that they represent a long-lived family of cells that differentiate into novel dendritic cells upon microbiologic stimulation.
鉴于浆细胞样树突状细胞具有产生I型干扰素的巨大潜力，很明显它们是宿主抵御病毒和各种病原体的主要参与者。浆细胞样树突状细胞最初在人类中被鉴定出来，最近小鼠中的对应细胞也已被分离出来。本综述尽可能着重于比较这两个物种的细胞。小鼠和人类的浆细胞样树突状细胞在表面表型上非常相似，并且它们对致病性刺激表现出相似的反应。小鼠浆细胞样树突状细胞的发现使得能够进一步研究这些细胞的生物学特性，现在很清楚它们代表了一类长寿的细胞家族，在微生物刺激下会分化为新型树突状细胞。
