Brière Francine, Bendriss-Vermare Nathalie, Delale Thomas, Burg Stéphanie, Corbet Christophe, Rissoan Marie Clotilde, Chaperot Laurence, Plumas Joël, Jacob Marie-Christine, Trinchieri Giorgio, Bates Elizabeth E M
Laboratory for Immunological Research, Schering-Plough, Dardilly, France.
Hum Immunol. 2002 Dec;63(12):1081-93. doi: 10.1016/s0198-8859(02)00746-2.
Human plasmacytoid dendritic cells represent a rare population of leukocytes which produce high amounts of type I interferon in response to certain viruses. Although those cells were first described in 1958, there are still unsolved issues related to their origin and function. Recently, a leukemic counterpart of plasmacytoid dendritic cells was identified. Molecular approaches using either normal or leukemic plasmacytoid dendritic cells provide some new insights into the controversial lymphoid origin of those cells. The need for specific markers is still a critical aspect for the identification of plasmacytoid dendritic cells, whatever stage of differentiation, in normal as well as in pathological conditions. Hopefully, novel markers will allow delineation of the relationships between dendritic cells at different stages of differentiation/maturation along the myeloid and lymphoid lineages.
人类浆细胞样树突状细胞是一类罕见的白细胞，可响应某些病毒产生大量I型干扰素。尽管这些细胞于1958年首次被描述，但关于其起源和功能仍存在未解决的问题。最近，已鉴定出浆细胞样树突状细胞的白血病对应物。使用正常或白血病浆细胞样树突状细胞的分子方法为这些细胞有争议的淋巴起源提供了一些新见解。无论在正常还是病理条件下，无论处于何种分化阶段，特异性标志物对于浆细胞样树突状细胞的鉴定仍然是一个关键方面。有望新型标志物将有助于描绘沿髓系和淋巴系分化/成熟不同阶段的树突状细胞之间的关系。
