Fehniger Todd A, Cooper Megan A, Nuovo Gerard J, Cella Marina, Facchetti Fabio, Colonna Marco, Caligiuri Michael A
Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH 43210, USA.
Blood. 2003 Apr 15;101(8):3052-7. doi: 10.1182/blood-2002-09-2876. Epub 2002 Dec 12.
Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole.
自然杀伤（NK）细胞是先天性淋巴细胞，可提供对宿主早期抵御病原体至关重要的细胞因子。人类NK细胞的一个亚群（CD56(bright)）组成性表达高亲和力白细胞介素2（IL-2）受体并产生免疫调节细胞因子。在此，我们证明CD56(bright) NK细胞存在于人类淋巴结中，并且内源性T细胞衍生的IL-2通过NK高亲和力IL-2受体发挥作用，共刺激CD56(bright) NK细胞分泌干扰素-γ。因此，适应性免疫调节因子影响先天性细胞因子的产生，进而可能影响正在形成的抗原特异性免疫反应。这些数据显示了先天性和适应性人类淋巴细胞之间的动态相互作用，并强调了研究免疫成分之间的相互作用以全面理解免疫反应的重要性。
