Udaka Fukashi, Sawada Hideyuki, Kameyama Masakuni
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka 530-0005, Japan.
Ann N Y Acad Sci. 2002 Nov;977:411-5. doi: 10.1111/j.1749-6632.2002.tb04845.x.
An MRI-pathological correlation study was performed to determine the pathological background of white matter lesions depicted on MR images. The pathological findings were various combinations of myelin loss, axonal loss, scattered microinfarcts, astrogliosis, dilatation of perivascular space, and relative preservation of subcortical U-fibers. Concerning the dilated perivascular space, we proposed a new classification according to the present study: (1) état criblé in the basal ganglia and the thalamus, (2) état criblé in the cerebral white matter, (3) enlarged perivascular space of the lenticulostriate arteries, and (4) état criblé in other sites. In conclusion, when effects of white matter lesions on cognitive function are to be evaluated, it is necessary to clarify tissues in at least three sequences: T2-weighted, T1-weighted, and FLAIR method.
进行了一项MRI与病理相关性研究，以确定磁共振图像上显示的白质病变的病理背景。病理结果是髓鞘丢失、轴突丢失、散在微梗死、星形胶质细胞增生、血管周围间隙扩张以及皮质下U形纤维相对保留的各种组合。关于扩张的血管周围间隙，根据本研究我们提出了一种新的分类：（1）基底节和丘脑的筛状状态，（2）脑白质的筛状状态，（3）豆纹动脉的血管周围间隙扩大，以及（4）其他部位的筛状状态。总之，当要评估白质病变对认知功能的影响时，有必要在至少三个序列中明确组织：T2加权、T1加权和FLAIR方法。
