Vik-Mo H
Scand J Clin Lab Invest. 1977 Dec;37(8):697-703. doi: 10.1080/00365517709101851.
The effects of the antilipolytic agents nicotinic acid (NA) and sodium salicylate (SS) on the distribution of coronary blood flow during acute myocardial ischaemia were studied in open chest dogs. Fifteen min following experimental coronary artery occlusion, blood flow in the ischaemic myocardium was on average 28% of flow in the non-ischaemic myocardium. The reduction in blood flow in the ischaemic mycardium was more pronounced in the endocardial than in epicardial halves of the myocardium. No significant change in blood flow was observed after administration of NA or SS in either the ischemic or nonischemic part of the myocardium. Both drugs reduced the extent of myocardial ischaemic injury as shown by reduced epicardial ST-segment elevations. Arterial concentrations of fatty acids were lowered by NA or SS, whereas the mechanical activity of the heart remained unchanged. It is concluded that the reduction of acute myocardial ischaemic injury effected by NA or SS is not due to changes in myocardial blood flow, but more likely to lower myocardial oxygen demand related to reduced fatty acid utilization.
在开胸犬身上研究了抗脂解剂烟酸（NA）和水杨酸钠（SS）对急性心肌缺血期间冠状动脉血流分布的影响。实验性冠状动脉闭塞15分钟后，缺血心肌的血流量平均为非缺血心肌血流量的28%。缺血心肌血流量的减少在心肌的心内膜部分比心外膜部分更明显。在心肌的缺血或非缺血部分给予NA或SS后，未观察到血流量的显著变化。两种药物均降低了心肌缺血损伤的程度，表现为心外膜ST段抬高降低。NA或SS降低了动脉脂肪酸浓度，而心脏的机械活动保持不变。得出的结论是，NA或SS对急性心肌缺血损伤的减轻不是由于心肌血流的变化，而更可能是由于与脂肪酸利用减少相关的心肌氧需求降低。
