内罗毕羊病病毒是非洲绵羊和山羊的一种重要蜱传病原体，在亚洲也有发现。

Nairobi sheep disease virus, an important tick-borne pathogen of sheep and goats in Africa, is also present in Asia.

作者信息

Marczinke Beate I, Nichol Stuart T

机构信息

Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

Virology. 2002 Nov 10;303(1):146-51. doi: 10.1006/viro.2002.1514.

DOI:10.1006/viro.2002.1514

PMID:12482666

Abstract

Nairobi sheep disease (NSD) virus is the prototype of the tick-borne NSD serogroup, genus Nairovirus, family Bunyaviridae. It is highly pathogenic for sheep and goats, causes disease in humans, and is widespread throughout East Africa. Ganjam virus has caused disease in goats and humans in India. Due to their occurrence on different continents and association with different ticks, these viruses were considered distinct despite serologic cross-reactivity. Their S RNA genome segments and encoded nucleocapsid proteins were found to be 1590 nucleotides and 482 amino acids in length and differed by only 10 and 3% at nucleotide and amino acid levels, respectively. Genetic and serologic data demonstrate that Ganjam virus is an Asian variant of NSD virus. These viruses were phylogenetically more closely related to Hazara virus than Dugbe virus.

摘要

内罗毕绵羊病（NSD）病毒是布尼亚病毒科内罗病毒属蜱传NSD血清群的原型。它对绵羊和山羊具有高度致病性，可导致人类发病，在东非广泛传播。甘贾姆病毒在印度曾导致山羊和人类发病。由于这些病毒出现在不同大陆且与不同蜱虫相关，尽管存在血清学交叉反应，但它们仍被认为是不同的。它们的S RNA基因组片段和编码的核衣壳蛋白长度分别为1590个核苷酸和482个氨基酸，核苷酸和氨基酸水平上仅分别相差10%和3%。遗传和血清学数据表明，甘贾姆病毒是NSD病毒的亚洲变种。这些病毒在系统发育上与哈扎拉病毒的关系比与杜格贝病毒的关系更密切。