云南省怒江州蜱传病毒多样性的元转录组学研究。
Meta-transcriptomics for the diversity of tick-borne virus in Nujiang, Yunnan Province.
机构信息
Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Institute of Endemic Disease Control and Prevention, Dali, China.
State Key Laboratory for Biocontrol, School of Medicine, Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, Sun Yat-sen University, Shenzhen, China.
出版信息
Front Cell Infect Microbiol. 2023 Dec 15;13:1283019. doi: 10.3389/fcimb.2023.1283019. eCollection 2023.
Ticks, an arthropod known for transmitting various pathogens such as viruses, bacteria, and fungi, pose a perpetual public health concern. A total of 2,570 ticks collected from Nujiang Prefecture in Yunnan Province between 2017 and 2022 were included in the study. Through the meta-transcriptomic sequencing of four locally distributed tick species, we identified 13 RNA viruses belonging to eight viral families, namely, , , , , , , , and . The most prevalent viruses were members of the order , including three of , two were classified as , and one was associated with . However, whether they pose a threat to human health still remains unclear. Indeed, this study revealed the genetic diversity of tick species and tick-borne viruses in Nujiang Prefecture based on COI gene and tick-borne virus research. These data clarified the genetic evolution of some RNA viruses and furthered our understanding of the distribution pattern of tick-borne pathogens, highlighting the importance and necessity of monitoring tick-borne pathogens.
蜱虫是一种节肢动物，以传播各种病原体（如病毒、细菌和真菌）而闻名，一直是公共卫生关注的焦点。本研究共纳入了 2017 年至 2022 年间从云南省怒江州采集的 2570 只蜱虫。通过对当地分布的 4 种蜱虫的 meta 转录组测序，我们鉴定出了 13 种 RNA 病毒，隶属于 8 个病毒科，分别为,,,,,,,, 和 。最常见的病毒是目成员，其中包括 3 种，2 种被归类为 ，1 种与 有关。然而，它们是否对人类健康构成威胁仍不清楚。事实上，本研究基于 COI 基因和蜱传病毒研究，揭示了怒江州蜱种和蜱传病毒的遗传多样性。这些数据阐明了一些 RNA 病毒的遗传进化，并进一步加深了我们对蜱传病原体分布模式的理解，突出了监测蜱传病原体的重要性和必要性。
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