Microbial Containment Complex, National Institute of Virology (ICMR), Pune, India.
Indian J Med Res. 2009 Nov;130(5):514-9.
Ganjam virus (GANV), a member of genus Nairovirus of family Bunyavirdae is of considerable veterinary importance in India. Though, predominantly tick borne, GANV was also isolated from mosquitoes, man and sheep. Neutralizing and complement fixing antibodies to GANV have been detected in animal and human sera collected from different parts of the country. Thirty three strains of GANV have been isolated from India, mainly from Haemaphysalis ticks. The virus replicated in certain vertebrate and mosquito cell lines and found pathogenic to laboratory animals. One natural infection and five laboratory-acquired infections in men were also reported. GANV is antigenically related to Nairobi sheep disease virus (NSDV) of Africa, which is highly pathogenic for sheep and goats causing 70-90 per cent mortality among the susceptible population. Recent molecular studies have demonstrated that GANV is an Asian variant of NSDV and both these viruses are related to the dreaded Crimean Congo haemorrhagic fever (CCHF) group viruses. The versatility of the virus to replicate in different arthropod species, its ability to infect sheep, goat and man makes it an important zoonotic agent.
甘贾姆病毒（GANV）是布尼亚病毒科纳罗病毒属的一种病毒，在印度具有相当重要的兽医意义。尽管 GANV 主要通过蜱传播，但也从蚊子、人和绵羊中分离出来。从印度不同地区采集的动物和人类血清中检测到针对 GANV 的中和和补体固定抗体。从印度分离出 33 株 GANV，主要来自血红扇头蜱。该病毒在某些脊椎动物和蚊子细胞系中复制，并对实验动物具有致病性。还报告了一例自然感染和五例实验室获得性感染。GANV 与非洲的内罗毕绵羊病病毒（NSDV）具有抗原相关性，该病毒对绵羊和山羊具有高度致病性，在易感人群中导致 70-90%的死亡率。最近的分子研究表明，GANV 是 NSDV 的亚洲变体，这两种病毒与可怕的克里米亚-刚果出血热（CCHF）组病毒有关。该病毒在不同节肢动物物种中复制的多功能性、感染绵羊、山羊和人类的能力使其成为一种重要的人畜共患病原体。
