Bützow G H, Burkhardt A, Novak D, Becker K
Dtsch Med Wochenschr. 1976 Feb 27;101(9):329-34. doi: 10.1055/s-0028-1104084.
Both external and internal factors have to be thought of as causes of obliterative disease of liver veins. Pathogenetically, thrombosis or proliferative vascular disease (endophlebitis hepatica obliterans) may affect either large veins (with occlusion of the ostia) or small ones. Veno-occlusive disease, caused by pyrrolizidine derivatives, is a special form. Injection of contrast medium to the inferior vena cava and (or) the liver veins is the most important diagnostic method. In two personal cases there was secondary occlusion of the liver veins as a result of IVC thrombosis, while in a third case there was non-thrombotic proliferative disease of the wall of the small hepatic veins, closely similar to veno-occlusive disease. In a 19-year-old girl in whom thrombosis of the vena cava (with signs of liver-vein occlusion) occurred after pregnancy, revascularisation was achieved by fibrinolytic treatment.
肝静脉闭塞性疾病的病因必须考虑到外部和内部因素。从发病机制上讲，血栓形成或增殖性血管疾病（闭塞性肝静脉炎）可能影响大静脉（伴有开口闭塞）或小静脉。由吡咯里西啶衍生物引起的静脉闭塞性疾病是一种特殊形式。向下腔静脉和（或）肝静脉注射造影剂是最重要的诊断方法。在本人的两例病例中，肝静脉继发闭塞是由于下腔静脉血栓形成所致，而在第三例病例中，小肝静脉壁出现非血栓性增殖性疾病，与静脉闭塞性疾病极为相似。一名19岁女孩在产后发生下腔静脉血栓形成（伴有肝静脉闭塞体征），通过纤溶治疗实现了血管再通。
