O'Connor Peter B, Costello Catherine E, Earle William E
Department of Biochemistry, Boston University School of Medicine Mass Spectrometry Resource, Boston, Massachusetts 02118, USA.
J Am Soc Mass Spectrom. 2002 Dec;13(12):1370-5. doi: 10.1016/S1044-0305(02)00700-6.
A high voltage RF oscillator circuit has been designed and constructed for driving multipole ion guides. The circuit is tunable from 500 kHz to 1.5 MHz by changing a capacitor and provides 0-1000 V(p-p) that is controlled by a 0-10 V input using a negative feedback circuit. This inexpensive circuit uses a set of high voltage transistors oscillating in tandem and does not require tuning of the resonance drive frequency as the oscillator automatically resonates at the (LC)(-1/2) frequency. Matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry (MALDI-FTMS) mass spectra were acquired using this tunable RF oscillator circuit to allow transmission of protein ions in the 8.5-39 kDa range through the quadrupole ion guide from the ion source to the mass analyzer.
已设计并构建了一种用于驱动多极离子导向器的高压射频振荡器电路。通过改变一个电容器，该电路的可调范围为500 kHz至1.5 MHz，并通过负反馈电路由0至10 V输入控制提供0至1000 V（峰-峰值）。这个低成本的电路使用一组串联振荡的高压晶体管，并且由于振荡器会自动在(LC)(-1/2)频率处谐振，因此不需要调谐谐振驱动频率。使用这个可调射频振荡器电路采集了基质辅助激光解吸/电离-傅里叶变换质谱（MALDI-FTMS）质谱，以允许8.5至39 kDa范围内的蛋白质离子从离子源通过四极离子导向器传输到质量分析器。
