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一种用于傅里叶变换质谱的高压基质辅助激光解吸离子源，设计用于容纳具有不同表面的大尺寸靶材。

A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces.

作者信息

O'Connor Peter B, Budnik Bogdan A, Ivleva Vera B, Kaur Parminder, Moyer Susanne C, Pittman Jason L, Costello Catherine E

机构信息

Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

出版信息

J Am Soc Mass Spectrom. 2004 Jan;15(1):128-32. doi: 10.1016/j.jasms.2003.10.005.

DOI:10.1016/j.jasms.2003.10.005
PMID:14698563
Abstract

A new design for a high pressure MALDI-FTMS instrument is described and initial data are shown. The instrument incorporates a large, 10 cm x 10 cm, sample translation stage to accommodate and position the MALDI target. The new instrument allows coupling to a wide variety of surface techniques such as gel electrophoresis or surface plasmon resonance. Coupling to thin layer chromatography is shown. Furthermore, a new nozzle design allows high pressure collisional cooling sufficient to stabilize gangliosides while minimizing the gas load on the system.

摘要

本文描述了一种新型高压基质辅助激光解吸电离傅里叶变换质谱仪（MALDI-FTMS）的设计，并展示了初始数据。该仪器配备了一个大型的10厘米×10厘米的样品平移台，用于放置和定位MALDI靶材。新仪器能够与多种表面技术联用，如凝胶电泳或表面等离子体共振。文中展示了其与薄层色谱联用的情况。此外，一种新的喷嘴设计可实现高压碰撞冷却，足以稳定神经节苷脂，同时将系统中的气体负载降至最低。

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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry of underivatized and permethylated gangliosides.未经衍生和全甲基化神经节苷脂的基质辅助激光解吸电离飞行时间质谱分析。
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