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妊娠期的性类固醇与单胺代谢

Sexual steroids and monamine metabolism during gestation.

作者信息

Parvez S, Raza-Bukhari A, Harvez H

出版信息

Experientia. 1976 Jan 15;32(1):118-20. doi: 10.1007/BF01932658.

DOI:10.1007/BF01932658
PMID:1248573
Abstract

The experiments show influence of progesterone and estradiol on regulation of enzymes of monamine metabolism, MAO and COMP during pregnancy. Both the hormones inhibit enzymes MAO and COMPT in the adrenals when determined at 0 h parturition. Estradiol has stronger inhibitory effect than progesterone. The results provide evidence for important endocrine implication during pregnancy for processes of monamine regulation.

摘要

实验表明，孕期黄体酮和雌二醇对单胺代谢酶（单胺氧化酶和儿茶酚-O-甲基转移酶）的调节有影响。在分娩0小时测定时，这两种激素均抑制肾上腺中的单胺氧化酶和儿茶酚-O-甲基转移酶。雌二醇的抑制作用比黄体酮更强。这些结果为孕期单胺调节过程中的重要内分泌影响提供了证据。

相似文献

1
Sexual steroids and monamine metabolism during gestation.妊娠期的性类固醇与单胺代谢
Experientia. 1976 Jan 15;32(1):118-20. doi: 10.1007/BF01932658.
2
Progesterone mediated increase in monoamine stores and the regulation of enzymes of biosynthesis and metabolism in the adrenal gland during late pregnancy in the rat.孕酮介导的大鼠妊娠后期肾上腺中单胺储存量的增加以及生物合成和代谢酶的调节。
Steroids. 1975 Nov;26(5):579-89. doi: 10.1016/0039-128x(75)90052-5.
3
Hormone mediated changes in monoamine stores and regulation of enzymes of biosynthesis and metabolism in the rat adrenal gland. Influence of progesterone, estradiol, ACTH and testosterone administration.激素介导的大鼠肾上腺中单胺储备的变化以及生物合成和代谢酶的调节。孕酮、雌二醇、促肾上腺皮质激素和睾酮给药的影响。
Steroids. 1981 Jul;38(1):1-10. doi: 10.1016/0039-128x(81)90016-7.
4
Influence of repeated injections of estradiol during late pregnancy upon enzymes of monoamine metabolism and biosynthesis in the rat.妊娠后期重复注射雌二醇对大鼠单胺代谢及生物合成酶的影响。
Pharmacol Res Commun. 1976 Jun;8(3):283-94. doi: 10.1016/0031-6989(76)90018-7.
5
Effects of estrogens and progesterone on the catecholaminergic activity of the adrenal medulla in female rats.
Life Sci. 1988;42(9):1019-28. doi: 10.1016/0024-3205(88)90432-8.
6
Influence of estradiol-17 beta and progesterone on catechol-O-methyltransferase and monoamine oxidase activities in uterine artery and myometrium of ovariectomized pigs.17β-雌二醇和孕酮对去卵巢猪子宫动脉和子宫肌层中儿茶酚-O-甲基转移酶和单胺氧化酶活性的影响。
Arch Vet Pol. 1993;33(1-2):29-37.
7
Influence of progressive starvation upon brain and adrenal monoaminergic activity in developing rats of two different ages.渐进性饥饿对两种不同年龄发育中大鼠脑和肾上腺单胺能活性的影响。
Biol Neonate. 1979;35(5-6):224-34. doi: 10.1159/000241178.
8
The rate limiting control of enzymes monoamine oxidase and catechol-O-methyl transferase in the foetus and the adult by adreno-cortical hormones.肾上腺皮质激素对胎儿和成人中酶单胺氧化酶和儿茶酚-O-甲基转移酶的限速控制。
Experientia. 1973 Oct 15;29(10):1259-62. doi: 10.1007/BF01935106.
9
Activity of catecholamine degrading enzymes in rat adrenal medulla and cortex after acute and repeated stress.急性和反复应激后大鼠肾上腺髓质和皮质中儿茶酚胺降解酶的活性
Endocrinol Exp. 1975 Jun;9(2):79-86.
10
Variation in activity of monoamine metabolizing enzymes in rat liver during pregnancy.大鼠孕期肝脏中单胺代谢酶活性的变化。
Br J Pharmacol. 1975 Feb;53(2):241-6. doi: 10.1111/j.1476-5381.1975.tb07355.x.

本文引用的文献

1
THE DISPOSITION OF CATECHOLAMINES IN THE RAT UTERUS AND THE EFFECT OF DRUGS AND HORMONES.儿茶酚胺在大鼠子宫中的分布以及药物和激素的影响。
J Pharmacol Exp Ther. 1964 May;144:150-5.
2
A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.一种用于估算单胺氧化酶的灵敏且特异的检测方法。
Biochem Pharmacol. 1963 Dec;12:1439-41. doi: 10.1016/0006-2952(63)90215-6.
3
SEX STEROIDS, CARDIAC 3H-NOREPINEPHRINE, AND TISSUE MONOAMINE OXIDASE LEVELS IN THE RAT.大鼠体内的性类固醇、心脏3H-去甲肾上腺素及组织单胺氧化酶水平
Biochem Pharmacol. 1963 Dec;12:1417-9. doi: 10.1016/0006-2952(63)90211-9.
4
Relation between the oestrous cycle and the binding of catecholamines in the rat uterus.大鼠子宫发情周期与儿茶酚胺结合之间的关系。
Nature. 1963 May 11;198:547-8. doi: 10.1038/198547a0.
5
Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy.
Endocrinology. 1968 Apr;82(4):844-59. doi: 10.1210/endo-82-4-844.
6
Monoamine oxidase activity in the hypothalamus and various other brain areas and in some endocrine glands of the rat during the estrus cycle.大鼠发情周期中下丘脑及其他脑区和某些内分泌腺中的单胺氧化酶活性。
J Neurochem. 1970 Feb;17(2):261-8. doi: 10.1111/j.1471-4159.1970.tb02209.x.
7
Progesterone and 20-alpha-hydroxypregn-4-en-3-one in plasma, ovaries and uteri during pregnancy in the rat.大鼠孕期血浆、卵巢及子宫中的孕酮和20-α-羟基孕-4-烯-3-酮
Endocrinology. 1970 Jul;87(1):43-8. doi: 10.1210/endo-87-1-43.
8
Effect of pretreatment with oestradiol, progesterone and DOPA on monoamine oxidase activity in the rat.雌二醇、孕酮和多巴预处理对大鼠单胺氧化酶活性的影响。
Nature. 1970 May 16;226(5246):642-3. doi: 10.1038/226642a0.
9
The effect of progesterone and oestradiol on rat uterine monoamine oxidase activity.孕酮和雌二醇对大鼠子宫单胺氧化酶活性的影响。
Biochem J. 1970 Apr;117(2):38P. doi: 10.1042/bj1170038pa.
10
Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy.大鼠发情周期和孕期卵巢静脉血中雌酮和雌二醇水平。
Biol Reprod. 1971 Dec;5(3):297-307. doi: 10.1093/biolreprod/5.3.297.