大鼠孕期肝脏中单胺代谢酶活性的变化。
Variation in activity of monoamine metabolizing enzymes in rat liver during pregnancy.
作者信息
Parvez S, Parvez S H, Youdim M B
出版信息
Br J Pharmacol. 1975 Feb;53(2):241-6. doi: 10.1111/j.1476-5381.1975.tb07355.x.
Abstract
- Catechol-0-methyltransferase (COMT) and monoamine oxidase (MAO) activities in rat liver were measured during pregnancy, parturition and postpartum. Compared with activity in non-pregnant controls, both enzymes showed a significant decrease in activity which was most pronounced at day 18. 2. The metabolism of intravenously infused [3H]-adrenaline to [3H]-metanephrine and to [3H]-acidic metabolites was also significantly depressed during pregnancy but had returned to control values by the 21st day. 3. The effects of reserpine and/or nialamide on hepatic COMT and MAO were studied in control and 20-day-pregnant rats. Their action on COMT activity differed in the two groups. MAO was inhibited to a similar extent in these groups whether the drugs were given separately or in combination. 4. It seems possible that the changes in endocrine function which occur during pregnancy are responsible for the observed alterations in enzyme activity.
摘要
- 在大鼠怀孕、分娩及产后期间，测定了其肝脏中儿茶酚-O-甲基转移酶（COMT）和单胺氧化酶（MAO）的活性。与未怀孕对照组的活性相比，两种酶的活性均显著降低，在第18天最为明显。2. 在怀孕期间，静脉注射的[3H]-肾上腺素代谢为[3H]-间甲肾上腺素和[3H]-酸性代谢物的过程也显著受到抑制，但到第21天时已恢复至对照值。3. 在对照大鼠和怀孕20天的大鼠中，研究了利血平和/或尼亚酰胺对肝脏COMT和MAO的影响。它们对COMT活性的作用在两组中有所不同。无论药物单独给药还是联合给药，这些组中MAO的抑制程度相似。4. 怀孕期间发生的内分泌功能变化似乎是观察到的酶活性改变的原因。
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