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1
Variation in activity of monoamine metabolizing enzymes in rat liver during pregnancy.大鼠孕期肝脏中单胺代谢酶活性的变化。
Br J Pharmacol. 1975 Feb;53(2):241-6. doi: 10.1111/j.1476-5381.1975.tb07355.x.
2
Progesterone mediated increase in monoamine stores and the regulation of enzymes of biosynthesis and metabolism in the adrenal gland during late pregnancy in the rat.孕酮介导的大鼠妊娠后期肾上腺中单胺储存量的增加以及生物合成和代谢酶的调节。
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3
Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.大鼠体内儿茶酚-O-甲基转移酶和单胺氧化酶对去甲肾上腺素和肾上腺素的代谢差异。
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Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase.查尔酮的硝基邻苯二酚衍生物作为单胺氧化酶和儿茶酚-O-甲基转移酶的抑制剂
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Evidence for saturation of catechol-O-methyltransferase by low concentrations of noradrenaline in perfused lungs of rats.低浓度去甲肾上腺素使大鼠灌注肺中儿茶酚-O-甲基转移酶饱和的证据。
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Effect of antihypertensive drugs on catechol-O-methyltransferase and monoamine oxidase activity in human term placental explants.抗高血压药物对人足月胎盘外植体中儿茶酚-O-甲基转移酶和单胺氧化酶活性的影响。
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9
Enzymes for epinephrine synthesis and metabolism in the myometrium, endometrium, red blood cells, and plasma of pregnant human subjects.妊娠女性受试者子宫肌层、子宫内膜、红细胞及血浆中肾上腺素合成与代谢相关的酶。
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The effects of soman in vitro on catechol-O-methyltransferase and monoamine oxidase activities in rabbit tissues.
J Biochem Toxicol. 1990 Fall;5(3):183-5. doi: 10.1002/jbt.2570050308.

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Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy.孕期人尿中雌激素和孕激素代谢物的动态变化。
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Triptans in pregnancy.妊娠期间使用曲坦类药物。
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Sexual steroids and monamine metabolism during gestation.妊娠期的性类固醇与单胺代谢
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Decreased phenylethanolamine-N-methyltransferase and catechol-O-methyltransferase activity in rabbit adrenal glands during pregnancy.孕期家兔肾上腺中苯乙醇胺 -N-甲基转移酶和儿茶酚 -O-甲基转移酶活性降低。
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Effects of thyroidectomy and L-thyroxine on adrenaline and noradrenaline concentrations in the adrenal glands and plasma of rats during the pro-oestrous phase of the oestrous cycle and pregnancy.甲状腺切除术和L-甲状腺素对大鼠发情周期动情前期和妊娠期肾上腺及血浆中肾上腺素和去甲肾上腺素浓度的影响。
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Physiological and pathological changes in tissue monoamine oxidase activity.组织单胺氧化酶活性的生理和病理变化。
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Comparative effects of hypophysectomy and adrenalectomy upon plasma and adrenal monoamines in pregnant and non-pregnant rats.垂体切除和肾上腺切除对妊娠及未妊娠大鼠血浆和肾上腺单胺的比较影响。
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本文引用的文献

1
THE STUDY OF MONOAMINE OXIDASE ACTIVITY BY HISTOCHEMICAL PROCEDURES.用组织化学方法研究单胺氧化酶活性
Biochem Pharmacol. 1965 Mar;14:223-6. doi: 10.1016/0006-2952(65)90186-3.
2
A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.一种用于估算单胺氧化酶的灵敏且特异的检测方法。
Biochem Pharmacol. 1963 Dec;12:1439-41. doi: 10.1016/0006-2952(63)90215-6.
3
The physiological disposition of H3-epinephrine and its metabolite metanephrine.H3-肾上腺素及其代谢产物间甲肾上腺素的生理处置
J Pharmacol Exp Ther. 1959 Dec;127:251-6.
4
Improved technique for the fluorimetric estimation of catecholamines.儿茶酚胺荧光测定的改进技术。
Acta Physiol Scand. 1961 Apr;51:348-55. doi: 10.1111/j.1748-1716.1961.tb02128.x.
5
Increased rate of metabolism of epinephrine and norepinephrine by sympathomimetic amines.拟交感胺类药物使肾上腺素和去甲肾上腺素的代谢速率增加。
J Pharmacol Exp Ther. 1960 Dec;130:367-9.
6
The adrenal cortex and the sympathetic nervous system.肾上腺皮质与交感神经系统。
Physiol Rev. 1957 Apr;37(2):155-95. doi: 10.1152/physrev.1957.37.2.155.
7
Monoamine oxidase activity in various parts of the rat brain during the estrous cycle.大鼠发情周期中大脑各部位的单胺氧化酶活性
Science. 1966 Nov 4;154(3749):649. doi: 10.1126/science.154.3749.649.
8
Cyclical variations in endometrial monoamine oxidase: correlation of histochemical and quantitative biochemical assays.子宫内膜单胺氧化酶的周期性变化：组织化学与定量生化检测的相关性
Biochem Pharmacol. 1968 May;17(5):721-6. doi: 10.1016/0006-2952(68)90008-7.
9
The contribution of the adrenal gland to the total amount of progesterone produced in the female rat.肾上腺对雌性大鼠体内孕酮总产量的贡献。
J Physiol. 1971 Apr;214(1):115-26. doi: 10.1113/jphysiol.1971.sp009422.
10
Monoamine oxidase activity in the hypothalamus and various other brain areas and in some endocrine glands of the rat during the estrus cycle.大鼠发情周期中下丘脑及其他脑区和某些内分泌腺中的单胺氧化酶活性。
J Neurochem. 1970 Feb;17(2):261-8. doi: 10.1111/j.1471-4159.1970.tb02209.x.

大鼠孕期肝脏中单胺代谢酶活性的变化。

Variation in activity of monoamine metabolizing enzymes in rat liver during pregnancy.

作者信息

Parvez S, Parvez S H, Youdim M B

出版信息

Br J Pharmacol. 1975 Feb;53(2):241-6. doi: 10.1111/j.1476-5381.1975.tb07355.x.

DOI:10.1111/j.1476-5381.1975.tb07355.x
PMID:1170911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666292/
Abstract
  1. Catechol-0-methyltransferase (COMT) and monoamine oxidase (MAO) activities in rat liver were measured during pregnancy, parturition and postpartum. Compared with activity in non-pregnant controls, both enzymes showed a significant decrease in activity which was most pronounced at day 18. 2. The metabolism of intravenously infused [3H]-adrenaline to [3H]-metanephrine and to [3H]-acidic metabolites was also significantly depressed during pregnancy but had returned to control values by the 21st day. 3. The effects of reserpine and/or nialamide on hepatic COMT and MAO were studied in control and 20-day-pregnant rats. Their action on COMT activity differed in the two groups. MAO was inhibited to a similar extent in these groups whether the drugs were given separately or in combination. 4. It seems possible that the changes in endocrine function which occur during pregnancy are responsible for the observed alterations in enzyme activity.
摘要
  1. 在大鼠怀孕、分娩及产后期间，测定了其肝脏中儿茶酚-O-甲基转移酶（COMT）和单胺氧化酶（MAO）的活性。与未怀孕对照组的活性相比，两种酶的活性均显著降低，在第18天最为明显。2. 在怀孕期间，静脉注射的[3H]-肾上腺素代谢为[3H]-间甲肾上腺素和[3H]-酸性代谢物的过程也显著受到抑制，但到第21天时已恢复至对照值。3. 在对照大鼠和怀孕20天的大鼠中，研究了利血平和/或尼亚酰胺对肝脏COMT和MAO的影响。它们对COMT活性的作用在两组中有所不同。无论药物单独给药还是联合给药，这些组中MAO的抑制程度相似。4. 怀孕期间发生的内分泌功能变化似乎是观察到的酶活性改变的原因。