Kubicki Marek, Westin Carl-Fredrik, Maier Stephan E, Mamata Hatsuho, Frumin Melissa, Ersner-Hershfield Hal, Kikinis Ron, Jolesz Ferenc A, McCarley Robert, Shenton Martha E
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Mass 02301, USA.
Harv Rev Psychiatry. 2002 Nov-Dec;10(6):324-36. doi: 10.1080/10673220216231.
Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. In this paper, we review research studies that have applied DTI for the purpose of understanding neuropsychiatric disorders. We begin with a discussion of the principles involved in DTI, followed by a historical overview of magnetic resonance diffusion-weighted imaging and DTI and a brief description of several different methods of image acquisition and quantitative analysis. We then review the application of this technique to clinical populations. We include all studies published in English from January 1996 through March 2002 on this topic, located by searching PubMed and Medline on the key words "diffusion tensor imaging" and "MRI." Finally, we consider potential future uses of DTI, including fiber tracking and surgical planning and follow-up.
磁共振扩散张量成像(DTI)是一种可用于可视化和测量脑组织中水分子扩散的新技术;它在评估白质异常方面特别有用。在本文中,我们回顾了为理解神经精神疾病而应用DTI的研究。我们首先讨论DTI所涉及的原理,接着是磁共振扩散加权成像和DTI的历史概述以及几种不同图像采集和定量分析方法的简要描述。然后我们回顾该技术在临床人群中的应用。我们纳入了1996年1月至2002年3月期间发表的所有关于该主题的英文研究,这些研究是通过在PubMed和Medline上以关键词“扩散张量成像”和“MRI”进行搜索找到的。最后,我们考虑DTI未来可能的用途,包括纤维追踪、手术规划及随访。