Sperling R A, Bates J F, Chua E F, Cocchiarella A J, Rentz D M, Rosen B R, Schacter D L, Albert M S
Memory Disorders Unit, Department of Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.
J Neurol Neurosurg Psychiatry. 2003 Jan;74(1):44-50. doi: 10.1136/jnnp.74.1.44.
To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer's disease by functional magnetic resonance imaging (fMRI) during an associative encoding task.
10 young controls, 10 elderly controls, and seven patients with mild Alzheimer's disease were studied using fMRI during a face-name association encoding task. The fMRI paradigm used a block design with three conditions: novel face-name pairs, repeated face-name pairs, and visual fixation.
The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face-name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions.
The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer's disease compared with normal aging.
通过功能磁共振成像（fMRI）研究正常衰老和轻度阿尔茨海默病患者在联想编码任务期间大脑激活模式的变化。
在一项面孔-名字联想编码任务期间，使用fMRI对10名年轻对照者、10名老年对照者和7名轻度阿尔茨海默病患者进行研究。fMRI范式采用包含三种条件的组块设计：新的面孔-名字对、重复的面孔-名字对和视觉注视。
年轻和老年对照者主要在前额叶和顶叶皮质的激活模式上存在差异：在编码新的面孔-名字对时，老年对照者在额上回和额下回的激活明显少于年轻对照者，但在顶叶区域的激活多于年轻对照者。与老年对照者相比，阿尔茨海默病患者在海马结构的激活明显减少，但在内侧顶叶和后扣带回区域的激活增加。
与正常衰老相比，在阿尔茨海默病早期，新联想编码期间的fMRI激活模式存在差异改变。
