Lebon P, Moreau M C, Cohen L, Chany C
Proc Soc Exp Biol Med. 1975 May;149(1):108-12. doi: 10.3181/00379727-149-38753.
Ouabain, which inhibits specifically membrane-bound ATPase activity, also inhibits the establishment of the antiviral state induced by interferon. Once the antiviral state is established, ouabain is ineffective. This inhibitory effect is reversed by adding Na/K ions to the cells. On the contrary, interferon production is unaffected by the same concentrations of ouabain. It is of interest that in such interferon-yielding cells, ouabain decreases the antiviral state.
哇巴因能特异性抑制膜结合ATP酶活性，它也能抑制由干扰素诱导产生的抗病毒状态的建立。一旦抗病毒状态建立，哇巴因就无效了。通过向细胞中添加钠/钾离子可逆转这种抑制作用。相反，相同浓度的哇巴因对干扰素的产生没有影响。有趣的是，在这些产生干扰素的细胞中，哇巴因会降低抗病毒状态。
