克雅氏病传播至短尾猕猴（食蟹猴）。

Transmission of Creutzfeldt-Jakob disease to the stumptail macaque (Macaca arctoides).

作者信息

Espana C, Gajdusek D C, Gibbs C J, Osburn B I, Gribble D H, Cardinet G H, Chanock R M

出版信息

Proc Soc Exp Biol Med. 1975 Jul;149(3):723-4. doi: 10.3181/00379727-149-38886.

Abstract

The successful transmission of Creutzfeldt-Jakob disease from both affected human and chimpanzee brain to stumptail macaques has been accomplished. The incubation period of 5 yr was the same for both animals; however, the course of the disease was longer in the animal receiving the human brain. In both cases, initial mild symptoms slowly remitted only to reappear some 4 mo later. Muscle biopsies revealed changes suggestive of a mild neuropathy. In addition, there appeared to be an increased ability to incorporate 3H-thymidine in untreated cultures of lymphocytes from peripheral blood.

摘要

克雅氏病已成功地从受感染的人类和黑猩猩大脑传播给短尾猕猴。两种动物的潜伏期均为5年；然而，接受人类大脑的动物病程更长。在这两种情况下，最初的轻微症状缓慢缓解，仅在约4个月后再次出现。肌肉活检显示有提示轻度神经病变的变化。此外，外周血淋巴细胞未经处理的培养物中掺入3H-胸腺嘧啶核苷的能力似乎有所增强。