Wachtlová M, Chválová M, Holusa R, Palecek F
Physiol Bohemoslov. 1975;24(3):263-8.
The authors verified the possibility of modelling pneumonia by the intratracheal administration of carrageenin solution into the lungs of rats. The most satisfactory dose was found to be 0.5 ml 0.7% carrageenin solution administered at 40 degrees C. The disease, evaluated by the morphological and functional signs, culminated after two days. Both macroscopically and histologically the lungs displayed typical signs of catarrhal suppurative aspiration bronchopneumonia. Functionally, marked tachypnoea (mean 180 cycles/min as against 110 c/min in the conscious controls) and raised functional residual capacity were found. A drop in the respiration rate and in FRC after bilateral cervical vagotomy indicated that a reflex component participates in the origin of the above two signs.
作者通过向大鼠肺部气管内注射角叉菜胶溶液，验证了模拟肺炎的可能性。发现最适宜的剂量是在40摄氏度下注射0.5毫升0.7%的角叉菜胶溶液。通过形态学和功能体征评估，该疾病在两天后达到高峰。在宏观和组织学上，肺部均表现出卡他性化脓性吸入性支气管肺炎的典型体征。在功能方面，发现有明显的呼吸急促（平均每分钟180次，而清醒对照组为每分钟110次）以及功能残气量增加。双侧颈迷走神经切断术后呼吸频率和功能残气量下降，表明反射成分参与了上述两种体征的产生。
