Drazen J M, Loring S H, Regan R
J Appl Physiol. 1976 Jan;40(1):110-13. doi: 10.1152/jappl.1976.40.1.110.
An analog computer to determine dynamic pulmonary compliance (C) and pulmonary resistance (R) on a breath-by-breath basis was tested in guinea pigs and dogs. C was determined by dividing volume by transpulmonary pressure at instants of zero flow. R was determined by the method of electrical subtraction at predetermined flows. In both species the computer outputs and the results of direct analysis were in close agreement. In guinea pigs, the device reliably followed the rapid three- to fourfold changes in C and R resulting from histamine infusion. In unanesthetized dogs, the dispersion and mean values of C and R were similar by the two methods.
一种用于逐次测定动态肺顺应性（C）和肺阻力（R）的模拟计算机在豚鼠和狗身上进行了测试。C通过在零流量瞬间将容积除以跨肺压来确定。R通过在预定流量下的电减法来确定。在这两个物种中，计算机输出结果与直接分析结果非常吻合。在豚鼠中，该装置能够可靠地跟踪因注入组胺而导致的C和R迅速的三到四倍变化。在未麻醉的狗中，两种方法测得的C和R的离散度和平均值相似。
