Patrick Lyn
Altern Med Rev. 2002 Dec;7(6):456-71.
Mercury exposure is the second-most common cause of toxic metal poisoning. Public health concern over mercury exposure, due to contamination of fish with methylmercury and the elemental mercury content of dental amalgams, has long been a topic of political and medical debate. Although the toxicology of mercury is complex, there is evidence for antioxidant protection in the prevention of neurological and renal damage caused by mercury toxicity. Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an antioxidant and approved treatment for diabetic polyneuropathy for 40 years. Research has attempted to identify the role of antioxidants, glutathione and alpha-lipoic acid specifically, in both mitigation of heavy metal toxicity and direct chelation of heavy metals. This review of the literature will assess the role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.
汞暴露是第二常见的有毒金属中毒原因。由于鱼类被甲基汞污染以及牙科汞合金中的元素汞含量，公众对汞暴露的健康担忧长期以来一直是政治和医学辩论的话题。尽管汞的毒理学很复杂，但有证据表明抗氧化保护在预防汞毒性引起的神经和肾脏损伤方面具有作用。α-硫辛酸是丙酮酸和α-酮戊二酸脱氢酶的辅酶，在德国已作为抗氧化剂使用，并被批准用于治疗糖尿病性多发性神经病40年。研究试图确定抗氧化剂，特别是谷胱甘肽和α-硫辛酸，在减轻重金属毒性和直接螯合重金属方面的作用。这篇文献综述将评估谷胱甘肽和α-硫辛酸在汞中毒治疗中的作用。
