高暴露于六氯苯人群的血清有机氯和尿卟啉模式

Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene.

作者信息

Sunyer Jordi, Herrero Carmen, Ozalla Dolores, Sala Maria, Ribas-Fitó Núria, Grimalt Joan, Basagaña Xavier

机构信息

Respiratory and Environmental Research Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Catalonia, Spain.

出版信息

Environ Health. 2002 Jul 19;1(1):1. doi: 10.1186/1476-069x-1-1.

DOI:10.1186/1476-069x-1-1

PMID:12495451

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC131010/

Abstract

BACKGROUND

Porphyria cutanea tarda (PCT) is caused by hexachlorobenzene (HCB) in several species of laboratory mammals, but the human evidence is contradictory. In a study among adults of a population highly exposed to HCB (Flix, Catalonia, Spain), the prevalence of PCT was not increased. We aimed at analysing the association of individual urinary porphyrins with the serum concentrations of HCB and other organochlorine compounds in this highly exposed population.

METHODS

A cross-sectional study on total porphyrins was carried out in 1994 on 604 inhabitants of the general population of Flix, older than 14 years. Of them, 241 subjects (comprising a random sample and the subgroup with the highest exposure) were included for the present study. The porphyrin profile was determined by high-pressure liquid chromatography. Serum concentrations of HCB, as well as common organochlorine compounds, were determined by gas chromatography coupled to electron capture detection.

RESULTS

Coproporphyrin I (CPI) and coproporphyrin III (CPIII) were the major porphyrins excreted, while uroporphyrins I and III were only detected in 2% and 36% of the subjects respectively, and heptaporphyrins I and III in 1% and 6%, respectively. CPI and CPIII decreased with increasing HCB concentrations (p < 0.05). This negative association was not explained by age, alcohol, smoking, or other organochlorine compounds. No association was found between uroporphyrin I and III excretion, nor heptaporphyrin excretion, and HCB. CPIII increased with smoking (p < 0.05).

CONCLUSION

HCB exposure in this highly exposed population did not increase urinary concentrations of individual porphyrins.

摘要

背景

迟发性皮肤卟啉症（PCT）在几种实验哺乳动物中由六氯苯（HCB）引起，但人类相关证据存在矛盾。在一项针对高度暴露于HCB的人群（西班牙加泰罗尼亚的弗利克斯）的成年人研究中，PCT的患病率并未增加。我们旨在分析这一高度暴露人群中个体尿卟啉与HCB及其他有机氯化合物血清浓度之间的关联。

方法

1994年对弗利克斯普通人群中604名14岁以上居民进行了一项关于总卟啉的横断面研究。其中，241名受试者（包括一个随机样本和暴露程度最高的亚组）纳入本研究。通过高压液相色谱法测定卟啉谱。通过气相色谱-电子捕获检测法测定HCB以及常见有机氯化合物的血清浓度。

结果

粪卟啉I（CPI）和粪卟啉III（CPIII）是排泄的主要卟啉，而尿卟啉I和III分别仅在2%和36%的受试者中检测到，七卟啉I和III分别在1%和6%的受试者中检测到。CPI和CPIII随着HCB浓度升高而降低（p < 0.05）。这种负相关关系无法用年龄、酒精、吸烟或其他有机氯化合物来解释。未发现尿卟啉I和III排泄以及七卟啉排泄与HCB之间存在关联。CPIII随着吸烟而增加（p < 0.05）。