孕期暴露于六氯苯（HCB）与西班牙多中心出生队列的生殖效应。
Prenatal exposure to hexachlorobenzene (HCB) and reproductive effects in a multicentre birth cohort in Spain.
机构信息
Public Health Division of Gipuzkoa, Basque Government, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain; Health Research Institute, Biodonostia, San Sebastián, Spain.
出版信息
Sci Total Environ. 2014 Jan 1;466-467:770-6. doi: 10.1016/j.scitotenv.2013.07.053. Epub 2013 Aug 25.
OBJECTIVE
To investigate the possible association between birth size or gestational length and maternal serum concentrations of hexachlorobenzene (HCB) in a population exposed to background levels.
METHODS
A total of 1568 mother-child pairs recruited in three Spanish areas (INMA Project) from 2004 to 2008 participated in the study. Multivariate analysis was performed between birth weight and length, weeks of gestation, preterm birth or small for gestational age and HCB concentrations in maternal serum.
RESULTS
The median concentration of HCB was 45.45 ng/g lipids. No association was found between HCB exposure levels and birth weight (β: -50.42 [-109.88; 9.04]), birth length (β: -0.07 [-0.32; 0.18]), gestation age (HR: 1.07 [0.94; 1.22]), small for gestational age (OR: 0.95 [0.56; 1.61]) and preterm birth (OR: 0.60 [0.29; 1.28]). Results remain similar after adjustment for other organochlorines.
CONCLUSION
Our findings support the idea that exposure to low levels of HCB does not affect the intrauterine growth nor the duration of gestation.
目的
探讨在接触背景水平的人群中，出生体重或胎龄与母体血清中六氯苯（HCB）浓度之间可能存在的关联。
方法
共有 1568 对母子于 2004 年至 2008 年在西班牙三个地区（INMA 项目）参与了这项研究。在母体血清 HCB 浓度与出生体重和长度、胎龄、早产或小于胎龄之间进行了多变量分析。
结果
HCB 的中位数浓度为 45.45ng/g 脂质。HCB 暴露水平与出生体重（β：-50.42[-109.88;9.04]）、出生长度（β：-0.07[-0.32;0.18]）、胎龄（HR：1.07[0.94;1.22]）、小于胎龄（OR：0.95[0.56;1.61]）和早产（OR：0.60[0.29;1.28]）之间均无关联。在调整其他有机氯化合物后，结果仍然相似。
结论
我们的研究结果支持这样一种观点，即接触低水平的 HCB 不会影响宫内生长或胎龄。
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