Morin C L, Roy C C, Lasalle R, Bonin A
J Pediatr. 1976 Feb;88(2):213-6. doi: 10.1016/s0022-3476(76)80984-5.
Jejunal biopsies were obtained from 37 children with cystic fibrosis, 16 with gluten-induced enteropathy, and 18 control subjects for the following studies: (1) disaccharidase activity, (2) L-ALA-L-Phe hydrolase activity, and (3) intestinal uptake of three 14C-labeled amino acids. Values were significantly reduced in the three determinations in patients with gluten-induced enteropathy as compared to control subjects. Lactase and L-ALA-L-Phe hydrolase activities were significantly reduced (p less than 0.01) in CF patients as compared to control subjects. Definite hypolactasia was also observed in 23% of the children with CF. Uptake of lysine was normal in CF patients whereas that of phenylalanine and cycloleucine was reduced as compared to control subjects. This study suggests an intestinal component to the malabsorption of patients with CF.
从37名囊性纤维化患儿、16名麸质诱发的肠病患儿以及18名对照受试者身上获取空肠活检组织，用于以下研究：(1) 双糖酶活性；(2) L-丙氨酸-L-苯丙氨酸水解酶活性；(3) 三种14C标记氨基酸的肠道摄取。与对照受试者相比，麸质诱发的肠病患者在这三项测定中的数值显著降低。与对照受试者相比，囊性纤维化患者的乳糖酶和L-丙氨酸-L-苯丙氨酸水解酶活性显著降低（p<0.01）。在23%的囊性纤维化患儿中也观察到了明确的乳糖酶缺乏。与对照受试者相比，囊性纤维化患者的赖氨酸摄取正常，而苯丙氨酸和环亮氨酸的摄取减少。这项研究提示囊性纤维化患者吸收不良存在肠道因素。
