囊性纤维化患者肠道葡萄糖和丙氨酸转运增强。
Enhanced intestinal glucose and alanine transport in cystic fibrosis.
作者信息
Baxter P, Goldhill J, Hardcastle J, Hardcastle P T, Taylor C J
机构信息
Department of Biomedical Science, The University, Sheffield.
出版信息
Gut. 1990 Jul;31(7):817-20. doi: 10.1136/gut.31.7.817.
Abstract
The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.
摘要
在患有囊性纤维化的儿童的肠道活检样本中，测量了与葡萄糖和丙氨酸主动转运相关的短路电流的升高。在整个测试浓度范围（2.5 - 35 mM）内，囊性纤维化组织中葡萄糖诱导的短路电流增加幅度大于对照样本，这反映了转运最大速率的增加。丙氨酸也得到了类似的结果。这些发现表明，在囊性纤维化中，与钠相关的营养物质主动转运增强。
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