Draper A, Cullinan P, Campbell C, Jones M, Newman Taylor A
Department of Occupational & Environmental Medicine, Royal Brompton Hospital & NHLI, 1b Manresa Road, London SW3 6LR, UK.
Occup Environ Med. 2003 Jan;60(1):76-7. doi: 10.1136/oem.60.1.76.
We report two cases of occupational asthma caused by sensitisation to powdered fungicides fluazinam and chlorothalonil, from the same fungicide formulation plant. Both developed work related lower respiratory symptoms after a latent interval of asymptomatic exposure. The diagnosis in each case was confirmed with a serial peak flow record in the workplace followed by specific inhalation tests. These fungicides are known to cause dermatitis; this report indicates that these compounds can induce specific immunological reactions in the airways as well as skin.
我们报告了两例职业性哮喘病例，病因是对来自同一杀菌剂配方厂的粉状杀菌剂氟啶胺和百菌清过敏。两人在无症状接触的潜伏期后均出现了与工作相关的下呼吸道症状。每例病例的诊断均通过在工作场所进行连续峰值流量记录，随后进行特异性吸入试验得以证实。已知这些杀菌剂会引起皮炎；本报告表明，这些化合物可在气道以及皮肤中诱发特异性免疫反应。
