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[(123)I] - FP - CIT单光子发射计算机断层扫描在以运动诱发性肌张力障碍为表现的帕金森病早期诊断中的应用

[(123)I]-FP-CIT-SPECT in the early diagnosis of PD presenting as exercise-induced dystonia.

作者信息

Katzenschlager Regina, Costa Durval, Gacinovic Svetislav, Lees Andrew J

机构信息

National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

出版信息

Neurology. 2002 Dec 24;59(12):1974-6. doi: 10.1212/01.wnl.0000037484.28297.66.

DOI:10.1212/01.wnl.0000037484.28297.66
PMID:12499495
Abstract

Isolated foot dystonia following exercise is a rare manifestation of early PD. It may precede the onset of parkinsonism by years and can be clinically indistinguishable from familial exercise-induced dystonia. The authors present a patient with dystonic claudication where dopamine transporter SPECT using (123)I-FP-CIT allowed early diagnosis of PD and enabled effective symptomatic treatment with a dopamine agonist.

摘要

运动后孤立性足部肌张力障碍是早期帕金森病的一种罕见表现。它可能在帕金森综合征发病前数年出现,临床上与家族性运动诱发性肌张力障碍难以区分。作者报告了一名患有肌张力障碍性跛行的患者,使用(123)I-FP-CIT的多巴胺转运体单光子发射计算机断层扫描(SPECT)实现了帕金森病的早期诊断,并通过多巴胺激动剂进行了有效的对症治疗。

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[(123)I]-FP-CIT-SPECT in the early diagnosis of PD presenting as exercise-induced dystonia.[(123)I] - FP - CIT单光子发射计算机断层扫描在以运动诱发性肌张力障碍为表现的帕金森病早期诊断中的应用
Neurology. 2002 Dec 24;59(12):1974-6. doi: 10.1212/01.wnl.0000037484.28297.66.
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Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia.通过[123I]β-CIT单光子发射计算机断层扫描测量的多巴胺转运体密度在多巴反应性肌张力障碍中是正常的。
Ann Neurol. 1998 Jun;43(6):792-800. doi: 10.1002/ana.410430614.
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Dopamine transporter imaging (123)I-FP-CIT (DaTSCAN) SPET in differential diagnosis of dopa-responsive dystonia and young-onset Parkinson's disease.多巴胺转运体成像(123)I - FP - CIT(DaTSCAN)单光子发射计算机断层扫描在多巴反应性肌张力障碍和早发性帕金森病鉴别诊断中的应用
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Commentary: Dopaminergic dysfunction in DYT1 dystonia.评论:DYT1型肌张力障碍中的多巴胺能功能障碍。
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