Hori Tatsuya, Akikawa Takako, Kawakami Eiichi, Tsutsui Toshihiko
Department of Reproduction, Nippon Veterinary and Animal Science University, Tokyo, Japan.
J Vet Med Sci. 2002 Nov;64(11):993-8. doi: 10.1292/jvms.64.993.
A long-acting prostaglandin F(2alpha) analogue, fenprostalene, was subcutaneously administered singly at doses of 5, 10, 25, 50, 100 or 150 microg on day 25 after ovulation during pregnancy in bitches (n=4 for each dosage), and maintenance of pregnancy, changes in plasma progesterone concentration, interval between the treatment and subsequent estrus and conception rate at that estrus were studied. Abortion was associated with a decrease in the plasma progesterone concentration below about 2 ng/ml, and the abortifacient effect was dose-dependent. Administration of 50 microg or more of fenprostalene induced abortion in all dogs 3 to 13 days after the treatment. The interval between administration and subsequent estrus was markedly shorter in the aborted bitches than in the non-aborted ones (P<0.01). The conception rate at the estrus in the aborted dogs was 50%, whereas all of the bitches who had not aborted became pregnant. The results indicate that a single administration of fenprostalene could induce abortion during mid-pregnancy in bitches, and the subsequent estrus may come early with a low conception rate.
长效前列腺素F(2α)类似物苯前列烯，于母犬孕期排卵后第25天，分别以5、10、25、50、100或150微克的剂量皮下单独给药（每个剂量组n = 4），并研究了妊娠维持情况、血浆孕酮浓度变化、给药至随后发情的间隔时间以及该发情期的受孕率。流产与血浆孕酮浓度降至约2纳克/毫升以下有关，且堕胎效果呈剂量依赖性。给予50微克或更多苯前列烯后，所有犬在治疗后3至13天发生流产。流产母犬给药至随后发情的间隔时间明显短于未流产母犬（P<0.01）。流产犬发情期的受孕率为50%，而所有未流产的母犬均受孕。结果表明，单次给予苯前列烯可诱导母犬妊娠中期流产，且随后发情可能提前，但受孕率较低。
