Sopwith W, Ashton M, Frost J A, Tocque K, O'Brien S, Regan M, Syed Q
Communicable Disease Surveillance Centre (North West), Vernon Pritchard Court, 57a Upper Northgate St, Chester, CH1 4EF, UK.
J Infect. 2003 Jan;46(1):35-45. doi: 10.1053/jinf.2002.1072.
To identify sources and routes of infection for sporadic cases of campylobacter infection in the North West of England.
Standard, structured questionnaires were used to gather epidemiological information from cases of campylobacter infection in the North West Region of England between 1997 and 1999. The strains of campylobacter isolated from these cases were identified and typed using serotyping and phage typing methods. Analysis of combined serotype and epidemiological data is presented.
Human campylobacter infection in the North West is seasonal and a new observation was a peak in cases in March each year. Drinking bird-pecked milk was a highly seasonal exposure that might be an indicator of environmental contamination with campylobacter. A possible environmental basis for seasonality of infection is discussed. Frequencies of risk exposures related to serotypes of cases are described and a potential association was demonstrated between Campylobacter jejuni HS6 and consumption of bird-pecked milk. Also, Campylobacter coli infections were more commonly associated with travel abroad than C. jejuni and a decreased proportion of C. jejuni HS2 and C. jejuni HS11 reported consumption of meat and unpasteurised milk (respectively). Contact with a sick animal may be a significant risk exposure in younger age groups and in those who do not consume poultry or meat. It is clear from this and other studies that the sources and vehicles of human campylobacter infection are numerous and interventions that target a single risk factor are unlikely to impact significantly on the overall burden of disease.
确定英格兰西北部散发性弯曲杆菌感染病例的感染源和感染途径。
使用标准的结构化问卷，收集1997年至1999年英格兰西北部地区弯曲杆菌感染病例的流行病学信息。从这些病例中分离出的弯曲杆菌菌株，采用血清分型和噬菌体分型方法进行鉴定和分型。呈现了血清型和流行病学数据的综合分析结果。
英格兰西北部的人类弯曲杆菌感染具有季节性，一项新的观察结果是每年3月病例数达到峰值。饮用被鸟类啄过的牛奶是一种季节性很强的暴露因素，可能是弯曲杆菌环境污染的一个指标。讨论了感染季节性的可能环境基础。描述了与病例血清型相关的风险暴露频率，并证明空肠弯曲杆菌HS6与饮用被鸟类啄过的牛奶之间存在潜在关联。此外，大肠弯曲杆菌感染比空肠弯曲杆菌感染更常与出国旅行有关，报告食用肉类和未巴氏消毒牛奶的空肠弯曲杆菌HS2和空肠弯曲杆菌HS11比例分别下降。在较年轻的年龄组以及不食用家禽或肉类的人群中，接触患病动物可能是一个重要的风险暴露因素。从本研究和其他研究中可以清楚地看出，人类弯曲杆菌感染的来源和传播媒介众多，针对单一风险因素的干预措施不太可能对疾病的总体负担产生重大影响。
