Book L S, Herbst J J, Jung A L
Pediatrics. 1976 Feb;57(2):201-4.
A prospective investigation was conducted to determine if infants with necrotizing enterocolitis had evidence of carbohydrate intolerance prior to the onset of clinical symptoms of advanced disease. Stool specimens were examined for fecal reducing substances with Clintest tablets from well, full-term infants and sick premature infants. Only two of 45 (4.4%) formula-fed, full-term infants demonstrated higher than 2+ fecal reducing substances. Ten of 14 (71%) formula-fed premature infants who developed necrotizing enterocolitis had higher than 2+ reducing substances detected in their stools. Daily measurement of fecal reducing substances can be a useful adjunct in the management of sick premature infants.
进行了一项前瞻性调查，以确定患有坏死性小肠结肠炎的婴儿在晚期疾病临床症状出现之前是否有碳水化合物不耐受的证据。使用Clintest片剂对健康足月儿和患病早产儿的粪便样本进行粪便还原物质检测。45名配方奶喂养的足月儿中只有2名（4.4%）粪便还原物质高于2+。14名发生坏死性小肠结肠炎的配方奶喂养早产儿中有10名（71%）粪便中检测到还原物质高于2+。每日检测粪便还原物质可作为患病早产儿管理中的一项有用辅助手段。
