Sann L, Guillermet F N, Barbe G, Bethenod M
Pediatrie. 1985 Jun;40(4):277-83.
A quantitative study of the fecal flora was carried out in 21 neonates with necrotizing enterocolitis (NEC), (4 infants being born at term) and 57 control infants (30 born at term and 27 born before term). In the population as a whole Klebsiella was detected more frequently in NEC than in the controls. This was especially true in premature infants where Klebsiella was found in 65% of the affected infants versus 33% of the controls (p less than 0,05), while no Klebsiella was detected in the 4 term infants with NEC and in 87% of the term controls. These data suggest that Klebsiella could play a role in the pathogenesis of NEC, especially in the premature infant. Therefore, it seems required to avoid the artificial selection of Klebsiella in the neonate.
对21例坏死性小肠结肠炎（NEC）新生儿（4例足月儿）和57例对照婴儿（30例足月儿和27例早产儿）进行了粪便菌群定量研究。在总体人群中，NEC患者中克雷伯菌的检出率高于对照组。在早产儿中尤其如此，65%的患NEC早产儿中发现了克雷伯菌，而对照组中这一比例为33%（p<0.05），而4例患NEC的足月儿和87%的足月儿对照组中未检测到克雷伯菌。这些数据表明，克雷伯菌可能在NEC的发病机制中起作用，尤其是在早产儿中。因此，似乎有必要避免在新生儿中人为选择克雷伯菌。
