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Conformational changes of nucleic acids and poly (d(A-T)-d(A-T)) caused by photoaddition of furocoumarins.补骨脂素光加成引起的核酸及聚（d（A-T）-d（A-T））的构象变化
Nucleic Acids Res. 1976 Jan;3(1):191-203. doi: 10.1093/nar/3.1.191.
2
Photochemical cross-linking of DNA-RNA helices by psoralen derivatives.补骨脂素衍生物对DNA-RNA螺旋的光化学交联作用。
J Mol Biol. 1977 Nov;116(4):661-79. doi: 10.1016/0022-2836(77)90265-0.
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Proc Natl Acad Sci U S A. 1973 Sep;70(9):2683-6. doi: 10.1073/pnas.70.9.2683.
4
Cross-link formation of phage lambda DNA in situ photochemically induced by the furocoumarin derivative angelicin.呋喃香豆素衍生物白芷香豆素原位光化学诱导噬菌体λ DNA的交联形成
Biochim Biophys Acta. 1980 Apr 30;607(2):215-20. doi: 10.1016/0005-2787(80)90074-x.
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6
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Z Naturforsch C. 1973 Jul-Aug;28(7):370-5. doi: 10.1515/znc-1973-7-802.
7
[The molecular mechanism of the photochemical reaction of furocoumarins with nucleic acids].[呋喃香豆素与核酸光化学反应的分子机制]
Z Gesamte Inn Med. 1976 Nov 15;31(22):920-3.
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本文引用的文献

1
PHOTOSENSITIZING FUROCOUMARINS: INTERACTION WITH DNA AND PHOTO-INACTIVATION OF DNA CONTAINING VIRUSES.光敏呋喃香豆素：与DNA的相互作用及含DNA病毒的光灭活
Experientia. 1965 Jan 15;21:22-4. doi: 10.1007/BF02136362.
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X-ray studies on two synthetic DNA copolymers.对两种合成DNA共聚物的X射线研究。
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3
Comparative study of lethal photosensitization of Sarcina lutea by 8-methoxypsoralen and by toluidine blue.8-甲氧基补骨脂素和甲苯胺蓝对藤黄八叠球菌致死性光致敏作用的比较研究
J Bacteriol. 1963 Feb;85(2):322-8. doi: 10.1128/jb.85.2.322-328.1963.
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Photosensitization of bacteria by furocoumarins and related compounds.呋喃香豆素及相关化合物对细菌的光敏作用。
Nature. 1958 Feb 22;181(4608):571-2. doi: 10.1038/181571a0.
5
Structural specificity for the photoinactivation of nucleic acids by furocoumarins.呋喃香豆素对核酸进行光灭活的结构特异性。
FEBS Lett. 1970 Sep 18;10(1):29-32. doi: 10.1016/0014-5793(70)80408-2.
6
Photoinactivation of Ehrlich ascites tumor cells in vitro obtained with skin-photosensitizing furocoumarins.用皮肤光敏性呋喃香豆素在体外对艾氏腹水癌细胞进行光灭活。
Experientia. 1967 May 15;23(5):335-6. doi: 10.1007/BF02144498.
7
[On the effective mechanism of the photodynamic furocumarine photoreaction of psoralen-(4-14C) with DNA, RNA, homopolynucleotides and nucleosides].[关于补骨脂素 -（4 - 14C）与DNA、RNA、同聚核苷酸和核苷的光动力呋喃香豆素光反应的作用机制]
Photochem Photobiol. 1967 May;6(5):341-54. doi: 10.1111/j.1751-1097.1967.tb08882.x.
8
Effect of structural alterations on the photosensitizing potency of furocoumarins (psoralens) and related compounds.结构改变对呋喃香豆素（补骨脂素）及相关化合物光敏效力的影响。
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9
Mechanism of skin photosensitization by forucoumarins. Photoreactivity of various furocouma- rins with native DNA and with ribosomal RNA.补骨脂素类对皮肤的光敏作用机制。各种呋喃香豆素与天然DNA及核糖体RNA的光反应性。
Biochim Biophys Acta. 1970 Sep 17;217(1):40-9.
10
A spectroscopic study of the excited states of coumarin.香豆素激发态的光谱研究。
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补骨脂素光加成引起的核酸及聚（d（A-T）-d（A-T））的构象变化

Conformational changes of nucleic acids and poly (d(A-T)-d(A-T)) caused by photoaddition of furocoumarins.

作者信息

Kittler L, Zimmer C

出版信息

Nucleic Acids Res. 1976 Jan;3(1):191-203. doi: 10.1093/nar/3.1.191.

DOI:10.1093/nar/3.1.191
PMID:1250697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342887/
Abstract

DNA's of various AT content, poly[d(A-T)-d(A-T)], and double-stranded RNA were irradiated with UV light at 365 nm in the presence of linear (xanthotoxin) or angular (angelicin) furocoumarins. The covalent photobinding is strongly dependent on the spatial arrangement of furocoumarin molecules at the polymer conformation. CD measurements demonstrate that the bifunctional photochemical binding of xanthotoxin with double-stranded DNA's and poly[d(A-T)-d(A-T)] is accompanied by conformational changes which involve probably decreasing helical twisting of the double helix. This effect is greatly enhanced with increasing AT content. The formation of A-like structures is very unlikely since the B leads to A transition induced by ethanol addition was found to be strongly suppressed in xanthotoxin photoreacted DNA. The B-type helix appears to be the most sensitive conformation with minor restriction to produce photochemically induced cross-links.

摘要

在直链（补骨脂素）或角型（白芷素）呋喃香豆素存在的情况下，用365nm的紫外光照射不同AT含量的DNA、聚[d(A-T)-d(A-T)]和双链RNA。共价光结合强烈依赖于呋喃香豆素分子在聚合物构象中的空间排列。圆二色性测量表明，补骨脂素与双链DNA和聚[d(A-T)-d(A-T)]的双功能光化学结合伴随着构象变化，这可能涉及双螺旋螺旋扭曲的减少。随着AT含量的增加，这种效应大大增强。由于发现在补骨脂素光反应的DNA中，乙醇添加诱导的B向A转变受到强烈抑制，所以形成A样结构的可能性非常小。B型螺旋似乎是最敏感的构象，对产生光化学诱导交联的限制较小。