Sack R Bradley, Siddique A Kasem, Longini Ira M, Nizam Azhar, Yunus Md, Islam M Sirajul, Morris J Glenn, Ali Afsar, Huq Anwar, Nair G Balakrish, Qadri Firdausi, Faruque Shah M, Sack David A, Colwell Rita R
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
J Infect Dis. 2003 Jan 1;187(1):96-101. doi: 10.1086/345865. Epub 2002 Dec 13.
How Vibrio cholerae spreads around the world and what determines its seasonal peaks in endemic areas are not known. These features of cholera have been hypothesized to be primarily the result of environmental factors associated with aquatic habitats that can now be identified. Since 1997, fortnightly surveillance in 4 widely separated geographic locations in Bangladesh has been performed to identify patients with cholera and to collect environmental data. A total of 5670 patients (53% <5 years of age) have been studied; 14.3% had cholera (10.4% due to V. cholerae O1 El Tor, 3.8% due to O139). Both serogroups were found in all locations; outbreaks were seasonal and often occurred simultaneously. Water-use patterns showed that bathing and washing clothes in tube-well water was significantly protective in two of the sites. These data will be correlated with environmental factors, to develop a model for prediction of cholera outbreaks.
霍乱弧菌如何在全球传播以及在流行地区决定其季节性高峰的因素尚不清楚。霍乱的这些特征被推测主要是与现在可以识别的水生栖息地相关的环境因素的结果。自1997年以来，在孟加拉国4个地理位置广泛分隔的地区进行了每两周一次的监测，以识别霍乱患者并收集环境数据。共研究了5670名患者（53%年龄小于5岁）；14.3%患有霍乱（10.4%由霍乱弧菌O1埃尔托生物型引起，3.8%由O139引起）。在所有地点均发现了这两种血清群；疫情具有季节性，且常常同时发生。用水模式表明，在两个地点，用管井水洗澡和洗衣服具有显著的保护作用。这些数据将与环境因素相关联，以建立一个预测霍乱疫情的模型。
