Halstead S B, Marchette N J, Sung Chow J S, Lolekha S
Proc Soc Exp Biol Med. 1976 Jan;151(1):136-9. doi: 10.3181/00379727-151-39160.
Dengue 2 virus replication in peripheral blood leukocyte cultures from 10 of 13 Asian or Polynesian subjects with actively acquired dengue immunity and two of three infants with passively acquired dengue antibody. Only 2 of 11 cultures from nonimmune infants or children supported viral replication. This study establishes a parallel in the biological behavior of human and simian PBL with respect to the immunological dependence of dengue virus replication in vitro. Elucidation of the mechanism (or mechamisms) regulating growth of dengue virus in leukocytes from immune hosts may contribute to an understanding of the role that virus-leukocyte interactions play in the pathogenesis of human dengue illness.
登革2型病毒在13名具有主动获得性登革热免疫力的亚洲或波利尼西亚受试者中的10名以及3名具有被动获得性登革热抗体的婴儿中的2名的外周血白细胞培养物中进行复制。在非免疫婴儿或儿童的11份培养物中，只有2份支持病毒复制。本研究确立了人类和猿猴外周血淋巴细胞在登革病毒体外复制的免疫依赖性方面的生物学行为的相似性。阐明调节登革病毒在免疫宿主白细胞中生长的机制可能有助于理解病毒与白细胞相互作用在人类登革热疾病发病机制中所起的作用。
