Guzman M G, Kouri G, Soler M, Bravo J, Rodríguez de La Vega A, Vazquez S, Mune M
Departamento de Virología, Instituto de Medicina Tropical Pedro Kouri, Habana, Cuba.
Mem Inst Oswaldo Cruz. 1992 Oct-Dec;87(4):559-64. doi: 10.1590/s0074-02761992000400016.
During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorrhagic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X2 p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
在1981年古巴登革出血热/登革休克综合征（DHF/DSS）流行期间，支气管哮喘（BA）在登革出血热患者中常被发现为个人或家族既往病史。鉴于抗体依赖增强（ADE）在DHF/DSS的发病机制中起重要作用，我们决定研究登革2型病毒（D2V）在哮喘患者和健康人外周血白细胞（PBL）中的复制能力。在90%的哮喘患者和53.8%的对照组中，获得了具有显著D2V增强活性的PBL（X2 p < 0.01）。哮喘组的增强能力更高。这是第一项将BA与登革2型病毒免疫增强相关联的体外研究。所获得的结果支持了BA作为DHF/DSS危险因素的作用，正如流行病学数据中所描述的那样。
