Marchette N J, Halstead S B, O'Rourke T, Scott R M, Bancroft W H, Vanopruks V
Infect Immun. 1979 Apr;24(1):47-50. doi: 10.1128/iai.24.1.47-50.1979.
Cord blood leukocytes from neonates with maternal dengue antibody supported dengue 2 virus replication in vitro; those from neonates without maternal antibody did not. Cord bloods of infants born to dengue-immune mothers contained a potent enhancing factor which gradually decayed with age and which was absent from neonates born to nonimmune mothers. Permissiveness of cultures of washed peripheral blood leukocytes from infants with maternal antibody declined steadily with increasing age in parallel with the decay of maternal antibody, and the leukocytes were no longer permissive after 10 to 12 months. The demonstration of a dengue maternal infection-enhancing factor in human cord blood from dengue-immune mothers supports the hypothesis that severe primary dengue hemorrhagic fever with shock seen in Bangkok infants is related to maternal immune status.
来自有母体登革热抗体的新生儿的脐带血白细胞在体外支持登革2型病毒复制；而来自无母体抗体的新生儿的脐带血白细胞则不支持。登革热免疫母亲所生婴儿的脐带血中含有一种强效增强因子，该因子会随着年龄增长而逐渐衰减，非免疫母亲所生新生儿的脐带血中则不存在这种因子。有母体抗体的婴儿经洗涤的外周血白细胞培养物的易感性随着年龄增长以及母体抗体的衰减而稳步下降，10至12个月后白细胞不再具有易感性。在来自登革热免疫母亲的人类脐带血中证明存在登革热母体感染增强因子，这支持了曼谷婴儿中所见的严重原发性登革出血热伴休克与母体免疫状态相关的假说。
