Chuang Wen-Yu, Chen Tse-Ching, Hsu Hui-Ling, Lee Wei-Chen, Jeng Long-Bin, Huang Shiu-Feng
Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan.
J Formos Med Assoc. 2002 Nov;101(11):798-802.
Malignant transformation of liver cell adenoma and unequivocal hepatocellular carcinoma in resected liver cell adenomas are rare. We report two cases of liver cell adenoma with concomitant hepatocellular carcinoma. The first occurred in a 19-year-old male with an asymptomatic liver mass and was discovered incidentally. He had a history of nephrotic syndrome treated with oral prednisolone for 15 years. The second occurred in a 46-year-old female who was admitted due to right tubo-ovarian abscess. Computerized tomography scanning incidentally found a 10-cm liver mass in the right lobe. There was no history of oral contraceptive use. Both patients were negative for serum hepatitis B surface antigen and anti-hepatitis C virus antibody. Neither had cirrhosis. These two cases imply that malignant transformation of liver cell adenoma does occur, and that liver cell adenomas should be excised when malignant transformation is suspected.
肝细胞腺瘤的恶性转化以及切除的肝细胞腺瘤中明确的肝细胞癌都很罕见。我们报告两例伴有肝细胞癌的肝细胞腺瘤病例。第一例发生在一名19岁男性身上，有一个无症状肝脏肿块，是偶然发现的。他有肾病综合征病史，口服泼尼松龙治疗15年。第二例发生在一名46岁女性身上，因右输卵管卵巢脓肿入院。计算机断层扫描偶然发现右叶有一个10厘米的肝脏肿块。她没有口服避孕药史。两名患者血清乙肝表面抗原和抗丙肝病毒抗体均为阴性。两人都没有肝硬化。这两例病例表明肝细胞腺瘤确实会发生恶性转化，并且当怀疑有恶性转化时应切除肝细胞腺瘤。
