Jia X, Han C, Chen J
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wei Sheng Yan Jiu. 2001 May;30(3):168-9.
The chemopreventive effects of tea polyphenols and tea pigments on liver precancerous lesion in rats were investigated. The results showed that the density and area of GST-P in the tea-treated groups were significantly reduced as compared with the positive control group. Furthermore, tea polyphenols and tea pigments induced the expression of p21WAF1 protein, inhibited the expression of Bcl-2 protein and induced the expression of Bax protein. It is concluded that GST-P was significantly inhibited by tea polyphenols and tea pigments and inhibition of cell proliferation and induction of apoptosis may be the two important mechanisms.
研究了茶多酚和茶色素对大鼠肝脏癌前病变的化学预防作用。结果表明，与阳性对照组相比，茶处理组中谷胱甘肽S-转移酶胎盘型（GST-P）的密度和面积显著降低。此外，茶多酚和茶色素诱导p21WAF1蛋白表达，抑制Bcl-2蛋白表达并诱导Bax蛋白表达。得出结论：茶多酚和茶色素可显著抑制GST-P，抑制细胞增殖和诱导细胞凋亡可能是两个重要机制。
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