黏液虫巨大轴突中双脉冲钠失活与再激活的比较。
Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.
作者信息
Schauf C L
出版信息
Biophys J. 1976 Mar;16(3):245-8. doi: 10.1016/S0006-3495(76)85684-6.
Abstract
Values for the time constant of reactivation of the sodium conductance following depolarization sufficient to completely inactivate GNa have been compared over a 15 mV range of membrane potential with the time constants of inactivation during a depolarization prepulse. Over this range the reactivation time constants were consistently 30-50% larger than the inactivation time constants determined simultaneously at the same potential in the same axon. The data suggests that inactivation and reactivation do not occur by identical mechanisms, and therefore implies that there are at least three kinds of experimental procedures necessary to fully characterize the sodium inactivation process in any particular system.
摘要
在足以使钠电导完全失活的去极化后，钠电导再激活时间常数的值，已在15mV的膜电位范围内，与去极化预脉冲期间的失活时间常数进行了比较。在此范围内，再激活时间常数始终比在同一轴突中相同电位下同时测定的失活时间常数大30 - 50%。数据表明，失活和再激活并非通过相同机制发生，因此意味着，在任何特定系统中，要全面表征钠失活过程，至少需要三种实验程序。
相似文献
1
Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.黏液虫巨大轴突中双脉冲钠失活与再激活的比较。
Biophys J. 1976 Mar;16(3):245-8. doi: 10.1016/S0006-3495(76)85684-6.
2
Further studies of activation-inactivation coupling in Myxicola axons. Insensitivity to changes in calcium concentration.对黏液虫轴突中激活-失活偶联的进一步研究。对钙浓度变化不敏感。
Biophys J. 1975 Nov;15(11):1111-6. doi: 10.1016/S0006-3495(75)85887-5.
3
Internal cesium alters sodium inactivation in Myxicola.体内铯会改变黏液虫体内的钠失活。
Biophys J. 1978 Sep;23(3):473-7. doi: 10.1016/S0006-3495(78)85463-0.
4
Geographical distribution and inactivation kinetics in internally perfused Myxicola giant axons.内灌注的黏液虫巨型轴突中的地理分布和失活动力学
Biophys J. 1986 Mar;49(3):761-6. doi: 10.1016/S0006-3495(86)83702-X.
5
Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.三碘季铵酚对黏液虫巨大轴突钠电导的影响
J Physiol. 1982 Feb;323:157-71. doi: 10.1113/jphysiol.1982.sp014066.
6
Immobilization of intramembrane charge in Myxicola giant axons.黏液虫巨大轴突中膜内电荷的固定
J Physiol. 1979 Jan;286:157-71. doi: 10.1113/jphysiol.1979.sp012611.
7
Evidence for negative gating charges in Myxicola axons.黏液虫轴突中负向门控电荷的证据。
Biophys J. 1983 Jun;42(3):225-31. doi: 10.1016/S0006-3495(83)84390-2.
8
Internal cations, membrane current, and sodium inactivation gate closure in Myxicola giant axons.黏液虫巨大轴突中的内部阳离子、膜电流和钠失活门关闭
Biophys J. 1988 Dec;54(6):1027-38. doi: 10.1016/S0006-3495(88)83040-6.
9
Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.黏液虫轴突中的慢钠失活。第二种失活状态的证据。
Biophys J. 1976 Jul;16(7):771-8. doi: 10.1016/S0006-3495(76)85727-X.
10
Actions of the antidepressant drug imipramine on the voltage-clamped Myxicola giant axon.
J Pharmacol Exp Ther. 1975 May;193(2):669-75.
引用本文的文献
1
A slow component of gating current in crayfish giant axons resembles inactivation charge movement.小龙虾巨轴突中门控电流的一个缓慢成分类似于失活电荷移动。
Biophys J. 1983 Mar;41(3):245-9. doi: 10.1016/S0006-3495(83)84434-8.
2
Solvent substitution as a probe of channel gating in Myxicola. Effects of D2O on kinetic properties of drugs that occlude channels.溶剂置换作为探究黏液虫通道门控的一种方法。重水对阻塞通道药物动力学特性的影响。
Biophys J. 1982 Feb;37(2):441-52. doi: 10.1016/S0006-3495(82)84690-0.
3
Solvent substitution as a probe of channel gating in Myxicola. Differential effects of D2O on some components of membrane conductance.溶剂置换作为探究黏液虫通道门控的一种方法。重水对膜电导某些成分的不同影响。
Biophys J. 1980 May;30(2):295-305. doi: 10.1016/S0006-3495(80)85095-8.
4
Some kinetic and steady-state properties of sodium channels after removal of inactivation.失活去除后钠通道的一些动力学和稳态特性。
J Gen Physiol. 1981 Jan;77(1):1-22. doi: 10.1085/jgp.77.1.1.
5
Sodium current kinetics in cat atrial myocytes.猫心房肌细胞中的钠电流动力学。
J Physiol. 1987 Mar;384:169-97. doi: 10.1113/jphysiol.1987.sp016449.
6
Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.注射四乙铵的Myxicola巨轴突中的激活-失活偶联
Biophys J. 1976 Sep;16(9):985-9. doi: 10.1016/S0006-3495(76)85749-9.
7
Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.黏液虫轴突中的慢钠失活。第二种失活状态的证据。
Biophys J. 1976 Jul;16(7):771-8. doi: 10.1016/S0006-3495(76)85727-X.
8
Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.黏液虫轴突中钠尾电流的特征。与膜不对称电流的比较。
Biophys J. 1977 Jul;19(1):7-28. doi: 10.1016/S0006-3495(77)85559-8.
9
A fully coupled transient excited state model for the sodium channel. I. Conductance in the voltage clamped case.一种用于钠通道的完全耦合瞬态激发态模型。I. 电压钳制情况下的电导
J Math Biol. 1978 Mar 3;5(2):121-42. doi: 10.1007/BF00275895.
10
Immobilization of intramembrane charge in Myxicola giant axons.黏液虫巨大轴突中膜内电荷的固定
J Physiol. 1979 Jan;286:157-71. doi: 10.1113/jphysiol.1979.sp012611.
本文引用的文献
1
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.枪乌贼巨大轴突中膜电位对钠电导的双重作用。
J Physiol. 1952 Apr;116(4):497-506. doi: 10.1113/jphysiol.1952.sp004719.
2
The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei.外部钾离子对乌贼（莱氏拟乌贼）巨大轴突中钠电流失活的影响。
J Gen Physiol. 1969 Jun;53(6):685-703. doi: 10.1085/jgp.53.6.685.
3
Current- and voltage-clamped studies on Myxicola giant axons. Effect of tetrodotoxin.对黏液虫巨轴突的电流钳制和电压钳制研究。河豚毒素的作用。
J Gen Physiol. 1969 Dec;54(6):730-40. doi: 10.1085/jgp.54.6.730.
4
The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid, Loligo pealei.外部钾离子和长时间电压调节对乌贼（Loligo pealei）巨大轴突中钠电流幅度的影响。
J Gen Physiol. 1969 Nov;54(5):589-606. doi: 10.1085/jgp.54.5.589.
5
Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.黏液虫巨型轴突中钠电流的失活。与激活过程偶联的证据。
J Gen Physiol. 1972 Jun;59(6):659-75. doi: 10.1085/jgp.59.6.659.
6
Sodium currents in Myxicola axons. Nonexponential recovery from the inactive state.黏液虫轴突中的钠电流。从失活状态的非指数性恢复。
Biophys J. 1974 Feb;14(2):151-4. doi: 10.1016/S0006-3495(74)70006-6.
7
Temperature dependence of the ionic current kinetics of Myxicola giant axons.黏液虫巨型轴突离子电流动力学的温度依赖性。
J Physiol. 1973 Nov;235(1):197-205. doi: 10.1113/jphysiol.1973.sp010384.
8
Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.黏液虫巨型轴突中钠电流和钾电流的定量描述及计算动作电位
J Gen Physiol. 1973 Mar;61(3):361-84. doi: 10.1085/jgp.61.3.361.
Zotero 插件