注射四乙铵的Myxicola巨轴突中的激活-失活偶联
Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.
作者信息
Schauf C L, Pencek T L, Davis F A
出版信息
Biophys J. 1976 Sep;16(9):985-9. doi: 10.1016/S0006-3495(76)85749-9.
Abstract
Myxicola giant axons internally injected with tetraethylammonium chloride to block potassium currents were examined under voltage clamp. The sodium inactivation time constants obtained from the decline in INa during step depolarizations were substantially smaller than those obtained using conditioning prepulses to the same potentials and the ratios agreed with previous observations using TTX. Inactivation shifts were also measured and found to be comparable to previous results.
摘要
对内部注射氯化四乙铵以阻断钾电流的黏液管巨轴突进行了电压钳检查。在阶跃去极化期间从INa的下降获得的钠失活时间常数明显小于使用相同电位的条件预脉冲获得的时间常数，并且该比率与先前使用TTX的观察结果一致。还测量了失活偏移，发现与先前的结果相当。
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引用本文的文献
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本文引用的文献
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ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE.注射氯化四乙铵的乌贼巨轴突中的反常整流
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Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.黏液虫巨型轴突中钠电流的失活。与激活过程偶联的证据。
J Gen Physiol. 1972 Jun;59(6):659-75. doi: 10.1085/jgp.59.6.659.
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Sodium currents in Myxicola axons. Nonexponential recovery from the inactive state.黏液虫轴突中的钠电流。从失活状态的非指数性恢复。
Biophys J. 1974 Feb;14(2):151-4. doi: 10.1016/S0006-3495(74)70006-6.
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Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.黏液虫巨型轴突中钠电流和钾电流的定量描述及计算动作电位
J Gen Physiol. 1973 Mar;61(3):361-84. doi: 10.1085/jgp.61.3.361.
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Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.黏液虫巨大轴突中双脉冲钠失活与再激活的比较。
Biophys J. 1976 Mar;16(3):245-8. doi: 10.1016/S0006-3495(76)85684-6.
10
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Biophys J. 1975 Nov;15(11):1111-6. doi: 10.1016/S0006-3495(75)85887-5.
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