黏液虫轴突中的慢钠失活。第二种失活状态的证据。
Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.
作者信息
Schauf C L, Pencek T L, Davis F A
出版信息
Biophys J. 1976 Jul;16(7):771-8. doi: 10.1016/S0006-3495(76)85727-X.
Abstract
Sodium inactivation and reactivation have been examined in voltage-clamped Myxicola axons after long-lasting membrane depolarizations produced either directly by changes in holding potential or indirectly by elevation of external K+ concentration. The results suggest the existence of a second inactivated state of the sodium channel with associated voltage-dependent rate constants at least two orders of magnitude lower than those of the fast inactivation process commonly examined. No specific influence of external [K+] on slow Na+ inactivation could be detected.
摘要
在电压钳制的黏液虫轴突中，研究了通过改变钳制电位直接产生或通过提高外部钾离子浓度间接产生的长时间膜去极化后的钠失活和再激活。结果表明，存在钠通道的第二种失活状态，其相关的电压依赖性速率常数比通常研究的快速失活过程的速率常数至少低两个数量级。未检测到外部[K+]对缓慢钠失活有特定影响。
相似文献
1
Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.黏液虫轴突中的慢钠失活。第二种失活状态的证据。
Biophys J. 1976 Jul;16(7):771-8. doi: 10.1016/S0006-3495(76)85727-X.
2
Dendrotoxin blocks potassium channels and slows sodium inactivation in Myxicola giant axons.树眼镜蛇毒素可阻断钾通道，并减缓黏液虫巨型轴突中的钠失活。
J Pharmacol Exp Ther. 1987 Jun;241(3):793-6.
3
Inactivation in Myxicola giant axons responsible for slow and accumulative adaptation phenomena.黏液虫巨大轴突中的失活与缓慢累积适应现象有关。
J Physiol. 1981 Mar;312:531-49. doi: 10.1113/jphysiol.1981.sp013642.
4
Further studies of activation-inactivation coupling in Myxicola axons. Insensitivity to changes in calcium concentration.对黏液虫轴突中激活-失活偶联的进一步研究。对钙浓度变化不敏感。
Biophys J. 1975 Nov;15(11):1111-6. doi: 10.1016/S0006-3495(75)85887-5.
5
Activation-inactivation coupling in Myxicola giant axons injected with tetraethylammonium.注射四乙铵的Myxicola巨轴突中的激活-失活偶联
Biophys J. 1976 Sep;16(9):985-9. doi: 10.1016/S0006-3495(76)85749-9.
6
Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.黏液虫巨大轴突中双脉冲钠失活与再激活的比较。
Biophys J. 1976 Mar;16(3):245-8. doi: 10.1016/S0006-3495(76)85684-6.
7
Proceedings: Slow recovery of the inactivation of sodium conductance in Myxicola giant axons.
J Physiol. 1975 Jul;249(1):22P-24P.
8
Zonisamide enhances slow sodium inactivation in Myxicola.
Brain Res. 1987 Jun 9;413(1):185-8. doi: 10.1016/0006-8993(87)90168-5.
9
Characteristics of sodium tail currents in Myxicola axons. Comparison with membrane asymmetry currents.黏液虫轴突中钠尾电流的特征。与膜不对称电流的比较。
Biophys J. 1977 Jul;19(1):7-28. doi: 10.1016/S0006-3495(77)85559-8.
10
Anticonvulsants modify inactivation but not activation processes of sodium channels in Myxicola axons.
Can J Physiol Pharmacol. 1987 Jun;65(6):1220-5. doi: 10.1139/y87-192.
引用本文的文献
1
Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation.钠通道蛋白1.5（NaV1.5）突变体E1784K中电导-电压关系的去极化是由于快速失活的改变。
PLoS One. 2017 Sep 12;12(9):e0184605. doi: 10.1371/journal.pone.0184605. eCollection 2017.
2
Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit.在哺乳动物细胞中，β1亚基的共表达会阻碍NaV1.4钠通道的缓慢失活。
Pflugers Arch. 2009 Apr;457(6):1253-63. doi: 10.1007/s00424-008-0600-8. Epub 2008 Oct 22.
3
Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb.昆虫钠通道对恶二嗪杀虫剂茚虫威的生物活性代谢产物DCJW差异敏感性的分子基础
Neurotoxicology. 2006 Mar;27(2):237-44. doi: 10.1016/j.neuro.2005.10.004. Epub 2005 Dec 2.
4
Interaction between duration of activity and time course of recovery from slow inactivation in mammalian brain Na+ channels.哺乳动物脑钠通道中活动持续时间与慢失活恢复时间进程之间的相互作用。
J Neurosci. 1998 Mar 1;18(5):1893-903. doi: 10.1523/JNEUROSCI.18-05-01893.1998.
5
Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons.钠通道的长期失活导致海马锥体神经元树突动作电位衰减。
J Neurosci. 1997 Sep 1;17(17):6639-46. doi: 10.1523/JNEUROSCI.17-17-06639.1997.
6
Inactivation in Myxicola giant axons responsible for slow and accumulative adaptation phenomena.黏液虫巨大轴突中的失活与缓慢累积适应现象有关。
J Physiol. 1981 Mar;312:531-49. doi: 10.1113/jphysiol.1981.sp013642.
7
Slow recovery of the maximal rate of rise (Vmax) of the action potential in sheep cardiac Purkinje fibers.绵羊心脏浦肯野纤维动作电位最大上升速率（Vmax）恢复缓慢。
Pflugers Arch. 1982 Jul;394(1):90-3. doi: 10.1007/BF01108313.
8
Activation and inactivation characteristics of the sodium permeability in muscle fibres from Rana temporaria.林蛙肌纤维钠通透性的激活与失活特性
J Physiol. 1982 Mar;324:297-318. doi: 10.1113/jphysiol.1982.sp014114.
9
Evidence for negative gating charges in Myxicola axons.黏液虫轴突中负向门控电荷的证据。
Biophys J. 1983 Jun;42(3):225-31. doi: 10.1016/S0006-3495(83)84390-2.
10
Slow changes in currents through sodium channels in frog muscle membrane.蛙肌膜中钠通道电流的缓慢变化。
J Physiol. 1983 Jun;339:253-71. doi: 10.1113/jphysiol.1983.sp014715.
本文引用的文献
1
The after-effects of impulses in the giant nerve fibres of Loligo.枪乌贼巨大神经纤维冲动的后效应
J Physiol. 1956 Feb 28;131(2):341-76. doi: 10.1113/jphysiol.1956.sp005467.
2
The influence of external potassium on the inactivation of sodium currents in the giant axon of the squid, Loligo pealei.外部钾离子对乌贼（莱氏拟乌贼）巨大轴突中钠电流失活的影响。
J Gen Physiol. 1969 Jun;53(6):685-703. doi: 10.1085/jgp.53.6.685.
3
Current- and voltage-clamped studies on Myxicola giant axons. Effect of tetrodotoxin.对黏液虫巨轴突的电流钳制和电压钳制研究。河豚毒素的作用。
J Gen Physiol. 1969 Dec;54(6):730-40. doi: 10.1085/jgp.54.6.730.
4
The effects of external potassium and long duration voltage conditioning on the amplitude of sodium currents in the giant axon of the squid, Loligo pealei.外部钾离子和长时间电压调节对乌贼（Loligo pealei）巨大轴突中钠电流幅度的影响。
J Gen Physiol. 1969 Nov;54(5):589-606. doi: 10.1085/jgp.54.5.589.
5
Rectification in instantaneous potassium current-voltage relations in Myxicola giant axons.黏液虫巨大轴突瞬时钾电流 - 电压关系的校正
J Physiol. 1971 Sep;217(3):517-31. doi: 10.1113/jphysiol.1971.sp009583.
6
Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process.黏液虫巨型轴突中钠电流的失活。与激活过程偶联的证据。
J Gen Physiol. 1972 Jun;59(6):659-75. doi: 10.1085/jgp.59.6.659.
7
Sodium currents in Myxicola axons. Nonexponential recovery from the inactive state.黏液虫轴突中的钠电流。从失活状态的非指数性恢复。
Biophys J. 1974 Feb;14(2):151-4. doi: 10.1016/S0006-3495(74)70006-6.
8
Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons.黏液虫巨型轴突中钠电流和钾电流的定量描述及计算动作电位
J Gen Physiol. 1973 Mar;61(3):361-84. doi: 10.1085/jgp.61.3.361.
9
[Slow sodium inactivation in Ranvier's node membrane. Role of external potassium].[郎飞结膜中的慢钠失活。细胞外钾的作用]
Biull Eksp Biol Med. 1973 Sep;76(9):15-9.
10
Comparison of two-pulse sodium inactivation with reactivation in Myxicola giant axons.黏液虫巨大轴突中双脉冲钠失活与再激活的比较。
Biophys J. 1976 Mar;16(3):245-8. doi: 10.1016/S0006-3495(76)85684-6.
Zotero 插件