[阿利图斯纺织厂员工的恶性肿瘤发病率（1978 - 1997年）] - Suppr

Kuzmickiene Irena, Stukonis Mecys, Didziapetris Remigijus

Vilniaus universiteto Onkologijos institutas, Naviku epidemiologijos grupe, Polocko 2, 2007 Vilnius.

Medicina (Kaunas). 2002;38(10):1018-25.

UNLABELLED

The purpose of this study was to evaluate cancer incidence in the large cotton-manufacturing factory in Lithuania. Altogether 10,198 workers employed at least 1 year in 1969-1997 were included in the cohort and followed during the period 1978/01/01-1997/12/31. National cancer rates were used to calculate the expected number of cancer cases. The overall cancer risk for men was slightly higher than that in the general population (standardized incidence rate (SIR) 1.15, 95% confidence interval (95% CI) 0.98-1.34). A significant increase in the incidence of esophagus (11 observed cases, SIR 3.76, 95% CI 1.88-6.67) and slightly increased of lung (42 observed cases, SIR 1.26, 95% CI 0.91-1.70) cancer became evident. None of the cancer risk showed statistically significant excess cancer incidence in the textile-processing (spinning and weaving) departments (SIR 0.98). In the women cohort the level of the general incidence was very close to expected, standardized incidence rates (SIR) being 0.99 (95% CI 0.88-1.13). However, there was a significant increase in the number of cases of gall bladder (6 observed, SIR 3.19, 95% CI 1.17-6.95). The analysis of the results among textile-processing (spinning and weaving departments) workers indicated the elevated risk of breast cancer (44 observed cases, SIR 1.49, 95% CI 1.08-2.0) and cervical cancer (24 observed cases, SIR 1.68, 95% CI 1.08-2.50). The number of lung cancer cases in this group was a higher, but statistically not significant (5 observed cases, SIR 1.53, 95% CI 0.5-3.58). Increased SIR values were observed for > or = 10 years since the first exposure for all cancers, cervix uteri, ovary and kidney.

CONCLUSIONS

The overall cancer risk for men cohort was slightly higher than that in the general population. There was a significant increase in the number of cancer of the esophagus. The overall excess risk in women cohort was only for gall bladder, but for spinners and weavers the elevated risk was for cervix uteri and breast cancer. After 10 years of employment the excess risk was already for all cancers, cervix uteri, ovary and kidney malignant tumors.

未标注

本研究旨在评估立陶宛大型棉纺织厂的癌症发病率。该队列共纳入了1969年至1997年期间至少工作1年的10198名工人，并在1978年1月1日至1997年12月31日期间进行随访。采用全国癌症发病率来计算癌症病例的预期数量。男性的总体癌症风险略高于一般人群（标准化发病率（SIR）为1.15，95%置信区间（95%CI）为0.98 - 1.34）。食管癌发病率显著增加（观察到11例病例，SIR为3.76，95%CI为1.88 - 6.67），肺癌发病率略有增加（观察到42例病例，SIR为1.26，95%CI为0.91 - 1.70）。在纺织加工（纺纱和织布）部门，没有一种癌症风险显示出统计学上显著的癌症发病率过高（SIR为0.98）。在女性队列中，总体发病率水平与预期非常接近，标准化发病率（SIR）为0.99（95%CI为0.88 - 1.13）。然而，胆囊癌病例数显著增加（观察到6例，SIR为3.19，95%CI为1.17 - 6.95）。对纺织加工（纺纱和织布部门）工人的结果分析表明，乳腺癌（观察到44例病例，SIR为1.49，95%CI为1.08 - 2.0）和宫颈癌（观察到24例病例，SIR为1.68，95%CI为1.08 - 2.50）的风险升高。该组肺癌病例数较多，但在统计学上不显著（观察到5例病例，SIR为1.53，95%CI为0.5 - 3.58）。自首次接触以来≥10年的所有癌症、子宫颈癌、卵巢癌和肾癌的SIR值均有所升高。