Nelyubov M V
Institute of Immunopathology, Russian Academy of Natural Sciences, Moscow, Russia.
Bull Exp Biol Med. 2002 Oct;134(4):374-5. doi: 10.1023/a:1021964416215.
Structural changes in the liver and spleen of albino mice with Astrakhan scrub typhus were studied by electron microscopy. Rickettsia invasion and formation of granulomas induced structural (destructive) and metabolic changes in hepatocytes. Rickettsia were degraded in cytophagosomes and cytolysophagosomes of hepatic macrophages (Kupffer cells) and blood capillary endotheliocytes. In the spleen rickettsia were seen in the extracellular spaces and in various cell populations.
通过电子显微镜研究了感染阿斯特拉罕恙虫病的白化小鼠肝脏和脾脏的结构变化。立克次体的侵袭和肉芽肿的形成导致肝细胞发生结构（破坏）和代谢变化。立克次体在肝巨噬细胞（库普弗细胞）和毛细血管内皮细胞的吞噬体和溶酶体吞噬体中被降解。在脾脏中，立克次体可见于细胞外空间和各种细胞群体中。
