Hwang T S, Chu Y C, Kim Y B, Lim B U, Kang J S
Department of Pathology, College of Medicine, Inha University, Inchon, Korea.
J Korean Med Sci. 1993 Dec;8(6):437-45. doi: 10.3346/jkms.1993.8.6.437.
Scrub typhus, an acute febrile infectious disease caused by R. tsutsugamushi, has been reported from various parts of the far east and pacific rim of Asia including Korea. It is well known that all human pathogenic rickettsia share an affinity to endothelial cells of the small blood vessels and evoke vascular inflammation variably associated with a rash, microthrombi, and hemorrhage. We infected the ICR mice by inoculating sublethal doses of R. tsutsugamushi R19 strain intraperitoneally and observed the pathologic changes by time sequence. The histopathologic features of experimentally induced scrub typhus in the mice were generally nonspecific interstitial inflammations characterized by interstitial pneumonitis, periportal inflammation, multifocal hepatic necrosis, interstitial nephritis, sinusoidal engorgement, and lymphohistiocytic cell infiltration in lymph nodes and spleen. Contrary to the general features of other rickettsial diseases, the pathologic process of scrub typhus experimentally induced by R. tsutsugamushi R19 strain mainly involved the interstitial connective tissue but not the blood vessels.
恙虫病是由恙虫病东方体引起的一种急性发热性传染病，在包括韩国在内的远东和亚洲太平洋沿岸各地均有报道。众所周知，所有人类致病性立克次体均与小血管内皮细胞有亲和力，并引发与皮疹、微血栓和出血相关程度各异的血管炎症。我们通过腹腔内接种亚致死剂量的恙虫病东方体R19株感染ICR小鼠，并按时间顺序观察病理变化。实验诱导的小鼠恙虫病的组织病理学特征通常是非特异性间质性炎症，其特征为间质性肺炎、门周炎症、多灶性肝坏死、间质性肾炎、血窦充血以及淋巴结和脾脏中的淋巴细胞和组织细胞浸润。与其他立克次体病的一般特征相反，由恙虫病东方体R19株实验诱导的恙虫病病理过程主要累及间质结缔组织而非血管。
